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首页> 外文期刊>Journal of the Academy of Nutrition and Dietetics >Risk factors for predicting hypoglycemia in patients receiving concomitant parenteral nutrition and insulin therapy.
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Risk factors for predicting hypoglycemia in patients receiving concomitant parenteral nutrition and insulin therapy.

机译:接受肠胃外营养和胰岛素治疗的患者预测低血糖的危险因素。

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The occurrence of hypoglycemia in patients receiving parenteral nutrition (PN) is low, yet its consequences can be detrimental. Treatment of hyperglycemia with insulin to achieve optimal blood glucose control is challenging and potentially associated with increased risk of the development of hypoglycemia. The objective of this study was to determine the association of patient characteristics on the risk of hypoglycemia among patients receiving concomitant PN and insulin therapy. This retrospective cohort study was conducted from January 1, 2008, to December 31, 2011, and included 1,657 patients who received PN. There was a significant decrease in the occurrence of hypoglycemia observed over time: 9.1% (43 of 475) in 2008, 6.4% (30 of 468) in 2009, 5.8% (20 of 347) in 2010, and 3.5% (13 of 367) in 2011 (P=0.013). Patients in whom hypoglycemia developed had a significantly longer duration on PN (18.0 vs 8.1 days, P<0.0001) as well as more days requiring insulin in the PN (16.1 vs 2.7 days, P<0.0001). The strongest predictors of hypoglycemia were: receiving PN in the ICU (OR 1.86, 95% CI 1.16 to 3.01), history of diabetes (OR 2.10, 95% CI 1.26 to 3.51), days on PN (OR 0.93, 95% CI 0.91 to 0.95), and an insulin drip (OR 3.14, 95% CI 1.81 to 5.42). With the identification of patient factors that contribute to an increase in hypoglycemia, existing protocols can be modified to treat hyperglycemia and prevent hypoglycemia.
机译:接受肠外营养(PN)的患者低血糖的发生率很低,但其后果可能是有害的。用胰岛素治疗高血糖以实现最佳血糖控制具有挑战性,并可能与发生低血糖的风险增加相关。这项研究的目的是确定在接受PN和胰岛素治疗的同时,患者特征与低血糖风险之间的关系。这项回顾性队列研究于2008年1月1日至2011年12月31日进行,纳入了1657例接受PN的患者。随着时间的推移,低血糖发生率显着下降:2008年为9.1%(475中的43),2009年为6.4%(468中的30),2010年为5.8%(347中的20)和3.5%(13中的13) 367)在2011年(P = 0.013)。发生低血糖的患者在PN上的持续时间明显更长(18.0 vs 8.1天,P <0.0001),而在PN中需要胰岛素的天数更多(16.1 vs 2.7天,P <0.0001)。低血糖的最强预测因子是:在ICU中接受PN(OR 1.86,95%CI 1.16至3.01),糖尿病史(OR 2.10,95%CI 1.26至3.51),PN日(OR 0.93,95%CI 0.91)至0.95)和滴注胰岛素(或3.14,95%CI为1.81至5.42)。通过确定导致低血糖增加的患者因素,可以修改现有方案以治疗高血糖并预防低血糖。

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