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首页> 外文期刊>Journal of the American Pharmaceutical Association: APhA >Drug interaction between oral contraceptives and St. John's Wort: appropriateness of advice received from community pharmacists and health food store clerks.
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Drug interaction between oral contraceptives and St. John's Wort: appropriateness of advice received from community pharmacists and health food store clerks.

机译：口服避孕药与圣约翰草之间的药物相互作用：从社区药剂师和保健食品店员那里获得的建议是否适当。

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OBJECTIVE: To estimate the extent to which community pharmacists and health food store clerks provide appropriate advice regarding a drug interaction between oral contraceptives and St. John's wort (SJW). DESIGN: Cross-sectional study. SETTING: Three community pharmacy chains and three health food store chains in four highly populated counties in California. Participants: Community pharmacists (n=99) and health food store clerks (n=84). INTERVENTION: Investigators, posing as consumers, telephoned pharmacists and health food store clerks and asked the following question: "Is there a problem with taking SJW with birth control pills?" MAIN OUTCOME MEASURES: Respondents were classified based on their ability to correctly identify the drug interaction (yes or no) and on the overall appropriateness (i.e., the absence of incorrect advice) of their advice. Comparisons were made between men and women respondents and between pharmacists and health food store clerks. RESULTS: Community pharmacists were more likely than health food store clerks to correctly identify the drug interaction (50.5% versus 10.9%; Xchi(1 df) = 54.32, P < 0.001). Overall, 31.8% of respondents provided inappropriate advice that implied the absence of a drug interaction (26.3% of 99 pharmacists and 34.8% of 184 health food store clerks; Xchi(1 df) = 2.15, P = 0.14). Appropriateness of advice varied significantly among the three pharmacy chains (P < 0.001) and the three health food store chains (P < 0.05). Responses did not differ by gender of respondents (P = 0.18). CONCLUSION: Lack of awareness of the potentially serious drug interaction between SJW and oral contraceptives by those who sell these products places the public at risk. Training and education, more comprehensive product labeling, and policies to refer consumers to drug information centers are needed.
机译：目的：评估社区药剂师和保健食品店员在多大程度上就口服避孕药与圣约翰草（SJW）之间的药物相互作用提供适当的建议。设计：横断面研究。地点：加利福尼亚州四个人口稠密的县中的三个社区药房连锁店和三个健康食品商店连锁店。参与者：社区药剂师（n = 99）和保健食品商店店员（n = 84）。干预：调查人员冒充消费者，给药剂师和保健食品商店的店员打了电话，问了以下问题：“服用节育药服用SJW是否有问题？”主要观察指标：根据受访者正确识别药物相互作用的能力（是或否）和建议的总体适当性（即没有错误建议）进行分类。男性和女性受访者之间以及药师和保健食品店职员之间进行了比较。结果：社区药师比健康食品店职员更容易正确识别药物相互作用（50.5％比10.9％; Xchi（1 df）= 54.32，P <0.001）。总体而言，有31.8％的受访者提供了不存在药物相互作用的不适当建议（99位药剂师中的26.3％和184个保健食品店员中的34.8％; Xchi（1 df）= 2.15，P = 0.14）。在三个药房连锁店（P <0.001）和三个健康食品连锁店（P <0.05）之间，建议的适当性差异很大。受访者的性别没有差异（P = 0.18）。结论：销售这些产品的人对SJW和口服避孕药之间潜在的严重药物相互作用的认识不足，使公众处于危险之中。需要培训和教育，更全面的产品标签以及将消费者引到药品信息中心的政策。

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