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首页> 外文期刊>Clinical drug investigation >Association of polycystic ovaries with the use of valproic acid in jordanian epileptic patients
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Association of polycystic ovaries with the use of valproic acid in jordanian epileptic patients

机译：约旦癫痫患者多囊卵巢与丙戊酸的相关性

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Objective: To investigate the frequency of occurrence of polycystic ovaries (PCO) in women taking valproic acid (VPA) as monotherapy for epilepsy. Study design and patients: 163 epileptic patients were seen at the outpatient neurology clinic at Princess's Basma Teaching Hospital, Irbid, and Basheer Hospital, Amman, Jordan. A detailed medical history was taken from the patients followed by a clinical examination and vaginal ultrasonography of the ovaries. Results: 102 patients (62.5%) had primary generalised seizures, 46 patients (28.2%) had partial seizures and 15 patients (9.2%) had partial secondary general ised seizures. Mean age ± standard error of the mean (SEM) was 29.8+- 0.97 years. The duration of epilepsy and treatment with VPA were (mean+-SD) 9.1+-0.48 and 7.9+-0.4 years, respectively. The dose and serum concentrations of VPA were (mean+-SD) 983.9+-101.96mg and 52.7+-4.7 mg/L, respectively. Mean body mass index (BMI) was 25.6+-0.92 kg/m~2. The mean weight gain was 6.6+-1.3kg (range 2-24kg). Menstrual abnormalities were detected in 58 (35.6%) patients. Twelve patients (7.4%) had PCO; these patients were compared with 17 patients without PCO selected randomly. There was a statistically significant difference in testosterone level and BMI -values in patients with PCO compared with those without negative PCO. Patients with PCO had a mean ± SEM serum testosterone level of 1.2 ± 0.18 iag/L and BMI values of 29.24+-1.75 kg/m~2. However, patients without PCO had a serum testosterone level of 0.61+-0.1mug/L and a BMI of 21.91+-0.7 kg/m~2. Menstrual abnormalities were detected in all patients with PCO and in eight patients without PCO. Hirsutism was found in four cases with PCO and in one case with no PCO. There were no statistically significant differences in the duration of therapy, doses and serum concentrations of VPA in patients with PCO compared with those without PCO.Conclusion: These results suggest an association between the use of VPA and PCO, hyperandrogenism, obesity and menstrual abnormalities. For women receiving VPA therapy, clinicians should consider performing an assessment of ovarian structure and function, especially if these patients develop menstrual cycle disturbances during treatment.
机译：目的：探讨以丙戊酸（VPA）为单一疗法治疗癫痫的妇女多囊卵巢（PCO）的发生频率。研究设计和患者：在Irbid的公主巴斯玛教学医院和约旦安曼的Basheer医院的门诊神经内科诊所共观察到163名癫痫患者。从患者那里获得详细的病史，然后进行卵巢的临床检查和阴道超声检查。结果：原发性全身性癫痫发作102例（62.5％），部分性癫痫发作46例（28.2％），部分继发性全身发作15例（9.2％）。平均年龄±平均标准误差（SEM）为29.8±0.97年。癫痫持续时间和VPA治疗的时间分别（平均+ -SD）为9.1 + -0.48和7.9 + -0.4年。 VPA的剂量和血清浓度分别为（平均值±标准差）983.9±101.96mg和52.7±4.7mg / L。平均体重指数（BMI）为25.6 + -0.92 kg / m〜2。平均体重增加为6.6 + -1.3kg（2-24kg）。在58名（35.6％）患者中发现了月经异常。 12名患者（7.4％）患有PCO;将这些患者与17例未随机选择PCO的患者进行比较。与无PCO阴性的患者相比，PCO患者的睾丸激素水平和BMI值存在统计学差异。 PCO患者的平均血清睾丸激素±SEM水平为1.2±0.18 iag / L，BMI值为29.24±-1.75 kg / m〜2。然而，没有PCO的患者的血清睾丸激素水平为0.61 + -0.1mug / L，BMI为21.91 + -0.7kg / m〜2。在所有有PCO的患者和8例无PCO的患者中检测到月经异常。在4例PCO和1例无PCO的情况下发现多毛症。与没有PCO的患者相比，PCO患者的治疗时间，VPA剂量和血清浓度在统计学上无显着差异。结论：这些结果表明VPA和PCO的使用，雄激素过多，肥胖和月经异常之间存在关联。对于接受VPA治疗的女性，临床医生应考虑对卵巢结构和功能进行评估，尤其是如果这些患者在治疗期间出现月经周期障碍。

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