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Advances in spike localization with EEG dipole modeling.

机译:脑电偶极子模型在尖峰定位方面的进展。

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摘要

EEG interpretation by visual inspection of waveforms, using the assumption that activity at a given electrode is a representation of only the activity of the cortex immediately beneath it, has been the traditional form of EEG analysis since its inception. The relatively recent advent of digital EEG has allowed more advanced analysis of EEG data and has shown that the simple visual inspection described above is a simplistic form of analysis. This is especially true when one is attempting to localize an epileptogenic focus using EEG spikes or seizure onset data. Spatiotemporal analysis of scalp voltage fields has allowed for improved localization of likely cerebral origins of such waveforms. Equivalent dipole source modeling is one such technique and, although not perfect, provides improved characterization of spike and seizure sources as compared to previous methods when properly interpreted. The use of other modern techniques, such as 3D MRI reconstructions and realistic head models, can further improve accuracy of dipole localization and allow for the synthesis of EEG and imaging data, which may be invaluable, especially in cases of pre-surgical epilepsy evaluation.
机译:自成立以来,EEG分析一直是传统形式的EEG分析,它是通过目测检查波形来进行EEG解释的,即假设给定电极上的活动仅表示其下方皮质的活动。数字脑电图的相对较新出现允许对脑电图数据进行更高级的分析,并表明上述简单的目视检查是分析的一种简化形式。当尝试使用EEG峰值或癫痫发作数据来定位癫痫病灶时,尤其如此。头皮电压场的时空分析可以改善这种波形可能的大脑起源的定位。等效偶极子源建模就是这样一种技术,尽管不完善,但经过正确解释后,与以前的方法相比,它可以改善尖峰和癫痫源的特性。使用其他现代技术,例如3D MRI重建和逼真的头部模型,可以进一步提高偶极子定位的准确性,并允许合成EEG和成像数据,这可能是无价的,尤其是在手术前癫痫评估的情况下。

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