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首页> 外文期刊>Journal of the American College of Cardiology >Assessment of coronary flow reserve by coronary pressure measurement: comparison with flow- or velocity-derived coronary flow reserve.
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Assessment of coronary flow reserve by coronary pressure measurement: comparison with flow- or velocity-derived coronary flow reserve.

机译：通过冠状动脉压力测量评估冠状动脉血流储备：与流量或速度衍生的冠状动脉血流储备进行比较。

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OBJECTIVES: This study sought to assess the reliability of pressure-derived coronary flow reserve (CFR) compared with flow- or velocity-derived CFR. BACKGROUND: Coronary flow reserve has been reported to have important clinical implications for the evaluation and treatment of coronary artery disease. METHODS: Using a pressure guide wire, coronary pressure distal to the stenosis was measured at rest and during hyperemia in seven dogs with various degrees of stenosis and in 30 patients with angina (29 and 34 stenoses in total, respectively). Pressure at the tip of the guiding catheter was also recorded with a fluid-filled transducer system. Pressure-derived CFR was calculated by the square root of the pressure gradient across the stenosis (DeltaP) during hyperemia divided by DeltaP at rest, using a proprietary software system. At the same time, coronary flow was monitored proximal to the stenosis with a flow meter in the experimental dogs, and coronary flow velocity distal to the stenosis was assessed using a Doppler guide wire in patients with angina. Flow-derived (or velocity-derived) CFR was compared with pressure-derived CFR. RESULTS: Except for one stenosis that showed no DeltaP at rest, a significant correlation was obtained between pressure- and flow-derived CFR in the animal study (y = 1.05x - 0.03, r = 0.92, p = 0.0001). A significant correlation was also seen between pressure- and velocity-derived CFR in the human study, except in three stenoses with no resting DeltaP (y = 0.70x + 0.37, r = 0.85, p = 0.0001). CONCLUSIONS: Similar to flow (or velocity) measurement, CFR can be assessed by pressure measurement, except in stenoses with minor resting DeltaP.
机译：目的：本研究旨在评估压力衍生冠状动脉血流储备（CFR）与流量或速度衍生CFR的可靠性。背景：冠状动脉血流储备据报道对评估和治疗冠状动脉疾病具有重要的临床意义。方法：使用压力导丝，在七只具有不同程度狭窄程度的狗和30例心绞痛患者（分别为29和34个狭窄）中，在休息和充血期间测量狭窄远端的冠状动脉压力。还使用充满流体的换能器系统记录引导导管末端的压力。使用专有软件系统，通过充血期间狭窄（DeltaP）上的压力梯度的平方根除以静止时的DeltaP，来计算压力衍生的CFR。同时，在实验犬中使用流量计监测狭窄部位附近的冠状动脉血流量，并使用多普勒导丝对狭窄的冠状动脉狭窄患者的冠状动脉血流速度进行评估。将流量（或速度）CFR与压力（CFR）进行比较。结果：在动物研究中，除了一处狭窄显示无DeltaP静止状态外，在压力和血流CFR之间获得了显着相关性（y = 1.05x-0.03，r = 0.92，p = 0.0001）。在人体研究中，在压力和速度引起的CFR之间也发现了显着的相关性，除了三个没有静止DeltaP的狭窄（y = 0.70x + 0.37，r = 0.85，p = 0.0001）。结论：类似于流量（或速度）测量，CFR可以通过压力测量来评估，除了狭窄DeltaP狭窄的狭窄者。

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