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首页> 外文期刊>Journal of the American College of Cardiology >Using homeostatic peptides in decompensated heart failure a reasonable paradigm but a flawed practice?
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Using homeostatic peptides in decompensated heart failure a reasonable paradigm but a flawed practice?

机译:在失代偿性心力衰竭中使用稳态肽是一种合理的范例,但却是有缺陷的做法吗?

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摘要

The failing heart is not just an enlarged version of the normal heartIn 1981, de Bold et al. (2) described a potent diuretic and natriuretic factor derived from the atrial extracts of rats. Subsequent research has led to the characterization of a family of peptides now known as natriuretic peptides. With the emerging understanding of the natriuretic peptide system has come the hope of enhanced diagnosis, more exact prognostication, and novel therapy for the heart failure syndrome (3,4). As with any "work in progress," the status of each of these hopes waxes and wanes, but few new concepts or therapies have realized both the enthusiasm and the rancor experienced by natriuretic peptides.
机译:衰竭的心脏不仅仅是正常心脏的放大版。1981年,de Bold等人。 (2)描述了一种来自大鼠心房提取物的有效利尿和利钠因子。随后的研究导致了现在被称为利钠肽的肽家族的表征。随着对利钠肽系统的新认识,人们希望能够增强诊断,更准确的预后以及对心力衰竭综合征进行新颖的治疗(3,4)。如同任何“进行中的工作”一样,这些希望的状态每况愈下,但是很少有新的概念或疗法实现了利钠肽所经历的热情和怨恨。

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