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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Hand-motor dysfunction in depression: characteristics and pharmacological effects.
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Hand-motor dysfunction in depression: characteristics and pharmacological effects.

机译：抑郁症中的手运动功能障碍：特征和药理作用。

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摘要

Motor retardation is a relevant aspect of depression. Kinematic analysis of movements can be applied to explore which type of motor dysfunction is associated with depression and to examine motor side effects of antidepressants. Using this tool, we aimed to investigate fine motor performance in patients suffering from depression and to compare a selective noradrenaline re-uptake inhibitor (NARI) (reboxetine) and a selective serotonin reuptake inhibitor (SSRI) (citalopram) regarding motor side effects after 4 weeks of treatment. In the first study (I), we examined 37 depressed patients and 37 healthy subjects using a digitizing graphic tablet and kinematic analysis of handwriting and rapid drawing movements. Both groups were comparable regarding age, gender distribution, handedness (preponderance of right-handers) and educational level. In the second study (ll), we examined different types of hand movements in 16 depressed patients receiving citalopram (flexible dosage) and 12 depressed patients treated with reboxetine (varying dosage) using the afore-mentioned methods. Both groups were comparable regarding age, gender, handedness and the baseline Hamilton Depression Rating Scale total score. I: Depressed patients performed drawing with significantly less regular velocity than controls (p < 0.001), but normal velocity. Handwriting of depressed patients was abnormally slow (p = 0.04). II: Reboxetine led to a significant improvement of repetitive drawing movements in depression. In contrast, citalopram had no pronounced effects on hand movements in depressed patients. I: Irregular patterns of velocity peaks in depressed patients point to basal ganglia dysfunction and/or deficient activity of the sensorimotor cortex and the supplementary motor area as possible substrates of hand-motor disturbances in depression. II: Computer-aided analysis of hand movements is a sensitive tool for the registration of differential pharmaceutical effects on hand-motor function in depression.
机译：运动迟缓是抑郁症的一个相关方面。运动的运动学分析可用于探讨与抑郁相关的哪种运动功能障碍，并检查抗抑郁药的运动副作用。我们旨在使用该工具研究抑郁症患者的精细运动表现，并比较选择性去甲肾上腺素再摄取抑制剂（NARI）（瑞波西汀）和选择性5-羟色胺再摄取抑制剂（SSRI）（西酞普兰）4后的运动副作用数周的治疗。在第一个研究（I）中，我们使用数字化图形输入板以及笔迹和快速绘图运动的运动学分析，检查了37位抑郁症患者和37位健康受试者。两组在年龄，性别分布，惯用性（惯用右手者）和教育程度方面具有可比性。在第二项研究（II）中，我们使用上述方法检查了16名接受西酞普兰（自由剂量）的抑郁症患者和12名接受瑞波西汀治疗（不同剂量）的抑郁症患者的不同类型的手部动作。两组在年龄，性别，习惯和汉密尔顿抑郁量表基线总分方面均具有可比性。 I：抑郁症患者的绘画规则速度明显低于对照组（p <0.001），但速度正常。抑郁症患者的笔迹异常缓慢（p = 0.04）。 II：瑞波西汀可显着改善抑郁症中的重复绘画运动。相反，西酞普兰对抑郁症患者的手部动作没有明显影响。 I：抑郁症患者的速度峰值不规则模式表明基底神经节功能障碍和/或感觉运动皮层和辅助运动区域活动不足，可能是抑郁症中手运动障碍的可能原因。 II：计算机辅助的手部动作分析是一种用于识别抑郁症中不同药物作用对手运动功能的敏感工具。

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