Prediction of clinical response to antidepressants in patients with depression: neurophysiology in clinical practice.

Pogarell O; Juckel G; Norra C; Leicht G; Karch S; Schaaff N; Folkerts M; Ibrahim A; Mulert C; Hegerl U

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Prediction of clinical response to antidepressants in patients with depression: neurophysiology in clinical practice.

机译：抑郁症患者对抗抑郁药的临床反应预测：临床实践中的神经生理学。

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Brain monoaminergic neurotransmission is involved in the pathophysiology of various psychiatric disorders including depression. Reliable indicators of central monoaminergic activity might be helpful to specifically identify and differentiate dysfunctions in individual patients in order to selectively adjust medication and predict clinical response. In patients with depression, predictors of treatment response to serotonergic versus non-serotonergic (e.g., noradrenergic) antidepressants could be of considerable clinical relevance by avoiding unfavorable factors such as a prolonged duration of the disorder, risk of suicidality and therapy-resistance. Consequently, these tools might help to decrease direct and indirect costs of treatment. The loudness dependence of the N1/P2 component of auditory evoked potentials (LD) has been proposed as a noninvasive neurophysiological indicator of central serotonergic function. This review focuses on recent studies providing evidence for the validity of LD as an indirect serotonergic marker and highlights data on the clinical application in terms of prediction of treatment response in patients with depression.

机译：脑单胺能神经传递参与包括抑郁症在内的各种精神疾病的病理生理。中心单胺能活动的可靠指标可能有助于具体识别和区分个别患者的功能障碍，以便选择性地调整药物治疗和预测临床反应。在抑郁症患者中，通过避免不良因素（例如病程延长，自杀倾向和治疗耐药性）等不利因素，预测血清素能和非5-羟色胺（例如去甲肾上腺素能）抗抑郁药的治疗反应预测指标可能具有重要的临床意义。因此，这些工具可能有助于减少直接和间接的治疗费用。已提出听觉诱发电位（LD）的N1 / P2成分的响度依赖性是中央血清素能功能的非侵入性神经生理指标。这篇综述着重于最近的研究，为LD作为间接血清素能标记物的有效性提供了证据，并着重于临床应用方面的数据，以预测抑郁症患者的治疗反应。

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《Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS)》 |2007年第2期|共4页
作者
Pogarell O; Juckel G; Norra C; Leicht G; Karch S; Schaaff N; Folkerts M; Ibrahim A; Mulert C; Hegerl U;
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中图分类神经病学与精神病学;
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Clinical; Cancer patients and suicide and depression; prediction; therapeutic aspects; 抗抑郁药;

机译：临床;癌症患者和自杀与抑郁症;预测;治疗方面;抗抑郁药;

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1. Prediction of clinical response to antidepressants in patients with depression: neurophysiology in clinical practice. [J] . Pogarell O, Juckel G, Norra C, Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) . 2007,第2期

机译：抑郁症患者对抗抑郁药的临床反应预测：临床实践中的神经生理学。
2. Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort [J] . Raymond W. Lam, Roumen Milev, Susan Rotzinger, BMC Psychiatry . 2016,第1期

机译：发现抗抑郁反应的生物标志物：来自加拿大抑郁症生物标志物整合网络（CAN-BIND）的协议和首例患者队列的临床特征
3. Standardized Terminology of Electroencephalogram in Critical Patients of the American Society of Clinical Neurophysiology (ACNS- American Clinical Neurophysiology Society): Version 2012-Translation and Adaptation For the Portuguese Language [J] . Caboclo Luis Otavio, Ferrari-Marinho Taissa, Soares Silvado Carlos Eduardo Journal of Clinical Neurophysiology . 2016,第4期

机译：美国临床神经生理学协会（ACNS-美国临床神经生理学协会）的危重患者脑电图标准化术语：2012版-葡萄牙语的翻译和改编
4. A Real Time EEG Analysis System for the Prediction of Clinical Antidepressant Responses [C] . Shuo-Hong Hung, Ina Wu, Yi-Chen Li, 2018 IEEE 23rd International Conference on Digital Signal Processing . 2018

机译：用于临床抗抑郁反应预测的实时脑电图分析系统
5. Patient motivation for participation in clinical trials for depression: Development and validation of the Motivation for Clinical Trials Inventory -Depression (MCTI-D) [D] . Loraas, Emily L. 2006

机译：参与抑郁症临床试验的患者动机：临床试验动机-抑郁症（MCTI-D）的开发和验证
6. Clinical characteristic and fecal microbiota responses to probiotic or antidepressant in patients with diarrhea-predominant irritable bowel syndrome with depression comorbidity: a pilot study [O] . Lu Zhang, Yi-Xuan Liu, Zhe Wang, 2019

机译：腹泻型肠易激综合征合并抑郁症患者的临床特征和粪便微生物群对益生菌或抗抑郁药的反应：一项初步研究
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Prediction of clinical response to antidepressants in patients with depression: neurophysiology in clinical practice.

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