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首页> 外文期刊>Journal of Pharmacy and Pharmacology >Antihyperlipidaemic and antioxidant effect of the total flavonoids in Selaginella tamariscina (Beauv.) Spring in diabetic mice
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Antihyperlipidaemic and antioxidant effect of the total flavonoids in Selaginella tamariscina (Beauv.) Spring in diabetic mice

机译：卷柏卷柏总黄酮对糖尿病小鼠的降脂和抗氧化作用

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Objectives To investigate the antidiabetic, antihyperlipidaemic and antioxidant activity of total flavonoids in Selaginella tamariscina (Beauv.) Spring (TFST) in a mouse model of diabetes. Methods Normal mice, mice fed with a high-fat emulsion diet and streptozotocin (STZ)-induced diabetic mice were treated with TFST for 6 weeks. Serum glucose, insulin and lipid, hepatic steatosis, production of the protein visfatin and antioxidant indices were evaluated. Key findings TFST significantly decreased the concentration of fasting blood glucose, total cholesterol, triglycerides and low-density- lipoprotein cholesterol, while it increased the levels of insulin and high-density-lipoprotein cholesterol in diabetic mice. TFST also improved the results of the oral glucose tolerance test to a certain degree. Furthermore, both the free fatty acid levels in the liver and hepatic steatosis were ameliorated by TFST treatment. These changes may be be associated with decreased production of visfatin. Administration of TFST also significantly decreased the levels of malondialdehyde, nitric oxide and inducible nitric oxide synthase and increased the content of glutathione and the activity of superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in the liver. No change in blood glucose levels were observed in the normal mice treated with TFST. Conclusions TFST showed an excellent effect in reducing the high blood glucose level but had no effect on normal blood glucose level. The antidiabetic activity of TFST could be explained by its antioxidant and antihyperlipidaemic activity, which finally elevated the insulin sensitivity of liver.
机译：目的研究糖尿病小鼠模型中卷柏卷柏（Beauv。Spring）（TFST）中总黄酮的抗糖尿病，抗高血脂和抗氧化活性。方法对正常小鼠，高脂乳化饮食喂养的小鼠和链脲佐菌素（STZ）诱导的糖尿病小鼠进行TFST治疗6周。评估了血清葡萄糖，胰岛素和脂质，肝脂肪变性，visfatin蛋白的产生和抗氧化指数。主要发现TFST显着降低了空腹血糖，总胆固醇，甘油三酸酯和低密度脂蛋白胆固醇的浓度，同时增加了糖尿病小鼠中胰岛素和高密度脂蛋白胆固醇的水平。 TFST在一定程度上也改善了口服葡萄糖耐量试验的结果。此外，通过TFST治疗可改善肝脏和肝脂肪变性中的游离脂肪酸水平。这些变化可能与visfatin的产生减少有关。 TFST的施用还显着降低了肝脏中丙二醛，一氧化氮和诱导型一氧化氮合酶的水平，并增加了谷胱甘肽的含量以及超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和谷胱甘肽-S-转移酶的活性。在用TFST治疗的正常小鼠中未观察到血糖水平的变化。结论TFST对降低高血糖水平有很好的效果，但对正常血糖水平没有影响。 TFST的抗糖尿病活性可以通过其抗氧化剂和抗高血脂活性来解释，最终提高了肝脏的胰岛素敏感性。

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