...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Pharmacy and Pharmacology >Natural polymer-stabilized multiple water-in-oil-in-water emulsions: A novel dermal drug delivery system for 5-fluorouracil
【24h】

Natural polymer-stabilized multiple water-in-oil-in-water emulsions: A novel dermal drug delivery system for 5-fluorouracil

机译：天然聚合物稳定的多种水包油包水型乳液：一种新型的5-氟尿嘧啶皮肤药物递送系统

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives The aim of this study was to create multiple water-in-oil-in-water (W/O/W) emulsions with an increased long-term stability as skin delivery systems for the hydrophilic model drug 5-fluorouracil. Methods Multiple W/O/W emulsions were prepared in a one-step emulsification process, and were characterized regarding particle size, microstructure and viscosity. In-vitro studies on porcine skin with Franz-type diffusion cells, tape stripping experiments and attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR) were performed. Key findings The addition of Solagum AX, a natural polymer mixture of acacia and xanthan gum, led to multiple W/O/W emulsions with a remarkably increased long-term stability in comparison to formulations without a thickener. The higher skin diffusion of 5-fluorouracil from the multiple emulsions compared with an O/W-macroemulsion could be explained by ATR-FTIR. Shifts to higher wave numbers and increase of peak areas of the asymmetric and symmetric CH2 stretching vibrations confirmed a transition of parts of the skin lipids from an ordered to a disordered state after impregnation of porcine skin with the multiple emulsions. Conclusions Solagum AX is highly suitable for stabilization of the created multiple emulsions. Moreover, these formulations showed superiority over a simple O/W-macroemulsion regarding skin permeation and penetration of 5-fluorouracil.
机译：目的这项研究的目的是创造出多种水包油包水（W / O / W）乳液，作为亲水性模型药物5-氟尿嘧啶的皮肤递送系统，具有更高的长期稳定性。方法采用一步法乳化制备多种W / O / W乳液，并对其粒径，微观结构和粘度进行表征。用Franz型扩散池对猪皮肤进行了体外研究，胶带剥离实验和衰减全反射傅立叶变换红外光谱（ATR-FTIR）。主要发现与无增稠剂的配方相比，添加了刺槐胶和黄原胶的天然聚合物混合物Solagum AX导致了多种W / O / W乳液，其长期稳定性显着提高。 ATR-FTIR可以解释与O / W宏乳液相比，5-氟尿嘧啶从多种乳液中的更高的皮肤扩散性。向猪的皮肤中注入多种乳剂后，向较高的波数转移和不对称和对称的CH2拉伸振动峰面积增加证实了部分皮肤脂质从有序状态过渡到无序状态。结论Solagum AX非常适合稳定所产生的多种乳液。而且，这些制剂在皮肤渗透和5-氟尿嘧啶的渗透方面显示出优于简单的O / W-大分子乳液。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号