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首页> 外文期刊>Clinical nephrology >Cognition may be related to arterial pulsatility index in HD patients
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Cognition may be related to arterial pulsatility index in HD patients

机译：HD患者的认知可能与动脉搏动指数有关

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Aims: Hemodialysis (HD) patients have a heavy burden of subclinical cerebrovascular disease and cognitive changes consistent with a vascular etiology. Pulsatility index is associated with microangiopathy of cerebral blood vessels and an increased risk of cerebral infarction. The proposed study was to determine common carotid artery pulsatility index (CCAPI) and its relation to cognition in well-dialyzed HD patients with no history of stroke or dementia and matched controls. Methods: Observational, cross-sectional study of CCAPI and cognition in 37 hemodialysis outpatients and 18 matched controls with normal kidney function. Non-parametric analyses were used to compare variables between groups. Multiple regression and ANOVA models were used to adjust for risk factor differences. Results: Controls had a lower CCAPI than the HD group (1.7 ± 0.3 vs. 2.1 ± 0.4 cm/s, p = 0.006). HD patients scored significantly lower on all cognitive domains. Attention correlated with CCAPI in HD patients, independent of hypertension, diabetes, hyperlipidemia, and years on HD (r2 =-0.36, p = 0.01). CCAPI correlated with years on HD, independent of traditional cardiovascular risk factors. (r2 = 0.26, p = 0.04). Conclusion: In well-dialyzed hemodialysis patients with no history of stroke or dementia, CCAPI may correlate with cognitive function and represent a marker for underlying cerebral microvascular disease.
机译：目的：血液透析（HD）患者具有亚临床脑血管疾病的沉重负担，并且认知变化与血管病因一致。搏动性指数与脑血管微血管病变和脑梗死风险增加有关。拟议的研究旨在确定透析良好，没有中风或痴呆病史的HD患者以及相匹配的对照组的颈总动脉搏动指数（CCAPI）及其与认知的关系。方法：对37名血液透析门诊患者和18名肾功能正常的对照患者进行CCAPI和认知功能的观察，横断面研究。使用非参数分析来比较组之间的变量。多元回归和方差分析模型用于调整风险因素差异。结果：对照组的CCAPI低于HD组（1.7±0.3 vs. 2.1±0.4 cm / s，p = 0.006）。 HD患者在所有认知领域的得分均明显较低。 HD患者的注意力与CCAPI相关，与高血压，糖尿病，高脂血症和HD患者的年龄无关（r2 = -0.36，p = 0.01）。 CCAPI与HD高龄相关，独立于传统的心血管危险因素。 （r2 ＝ 0.26，p ＝ 0.04）。结论：在没有中风或痴呆病史的透析良好的血液透析患者中​​，CCAPI可能与认知功能相关，并代表潜在的脑微血管疾病的标志物。

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