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首页> 外文期刊>Clinical nephrology >Saliva urea nitrogen dipstick - a novel bedside diagnostic tool for acute kidney injury
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Saliva urea nitrogen dipstick - a novel bedside diagnostic tool for acute kidney injury

机译：唾液尿素氮试纸-急性肾损伤的新型床旁诊断工具

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Background and aims: Measurement of saliva urea nitrogen (SUN) may be valuable in the screening of kidney failure. Here we evaluate the diagnostic performance of SUN dipsticks in patients with acute kidney injury (AKI). Material and methods: We measured SUN and blood urea nitrogen (BUN) in hospitalized patients diagnosed with AKI based on Acute Kidney Injury Network (AKIN)-criteria. After collection, saliva was transferred to a colorimetric SUN dipstick. We then compared the resultant test-pad color to six standardized color fields indicating SUN of 5 - 14 (#1), 15 - 24 (#2), 25 - 34 (#3), 35 - 54 (#4), 55 - 74 (#5), and ≥ 75 (#6) mg/ dL, respectively. We assessed the performance of SUN and BUN to discriminate AKIN 3 from earlier stages by the area under receiver operating characteristic curves (AUC ROC). Results: We enrolled 44 patients (59.5 ± 18 years, 58% female; pre-renal AKI: 67%; renal 24%; post-renal 9%) in AKIN stages 1 (59%), 2 (16%), and 3 (25%). SUN and BUN levels were correlated (Spearman rank Rs = 0.69; p< 0.001, n = 44) with the highest correlation in AKIN 1 (Rs = 0.63, p = 0.001, n = 26). SUN allowed a significant discrimination of AKIN 3 from earlier stages (AUC ROC 0.91; 95% CI 0.80 - 1.0), which was comparable to the diagnostic performance of BUN (AUC ROC 0.90; 95% CI 0.78 - 1.0). Conclusions: SUN dipsticks allow the discrimination of AKIN 3 from earlier AKI stages. This low-technology approach may aid the screening of severe AKI in areas where laboratory resources are scarce.
机译：背景与目的：唾液尿素氮（SUN）的测量对肾衰竭的筛查可能有价值。在这里，我们评估SUN试纸在急性肾损伤（AKI）患者中的诊断性能。材料和方法：我们根据急性肾损伤网络（AKIN）标准对住院诊断为AKI的患者进行了SUN和血尿素氮（BUN）的测量。收集后，将唾液转移到比色SUN试纸中。然后，我们将得到的测试板颜色与六个标准色域进行比较，这些颜色域指示SUN分别为5-14（＃1），15-24（＃2），25-34（＃3），35-54（＃4），55 -分别为74（＃5）和≥75（＃6）mg / dL。我们通过接收器工作特性曲线（AUC ROC）下的面积评估了SUN和BUN的性能，以区分AKIN 3与早期阶段。结果：我们纳入了AKIN阶段1（59％），2（16％）和44例（59.5±18岁，女性58％;肾前AKI：67％;肾24％;肾后9％）。 3（25％）。 SUN和BUN水平相关（Spearman等级Rs = 0.69; p <0.001，n = 44）与AKIN 1的相关性最高（Rs = 0.63，p = 0.001，n = 26）。 SUN使AKIN 3与早期阶段（AUC ROC 0.91; 95％CI 0.80-1.0）有显着区别，这与BUN的诊断性能相当（AUC ROC 0.90; 95％CI 0.78-1.0）。结论：SUN量油尺可以区分AKIN 3与早期AKI阶段。这种技术含量低的方法可能有助于在实验室资源匮乏的地区筛查严重的AKI。

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