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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Correlation between P300 and EEG rhythm in schizophrenia.
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Correlation between P300 and EEG rhythm in schizophrenia.

机译：精神分裂症中P300与脑电节律的相关性。

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摘要

We hypothesized that cognitive deficits reflected by P300 abnormality and distorted EEG rhythm in schizophrenia, which might share the subcortical generation system, could be closely associated with each other. Our goal is to assess the relationship between P300 and EEG rhythm generation in schizophrenics. Quantitative EEG (QEEG) in resting condition and P300 during auditory oddball paradigm were recorded with 25 unmedicated patients. Additionally, lateral ventricular-brain ratio (LV-BR), which partially reflects thalamic volume, was measured using CT scan. Brief Psychotic Rating Scale (BPRS) and Scale for Assessment of Negative Symptoms (SANS) were also rated. P300 amplitudes at Pz positively correlated with theta and slow alpha power before pharmacotherapy, however, the correlation tended to be confined to fast alpha after pharmacotherapy. BPRS and SANS showed no significant correlation with QEEG. High frequency bands such as fast alpha and beta showed trends to correlate negatively to LV-BR. The lack of correlation between P300 amplitudes and fast alpha power before pharmacotherapy, which was restored after pharmacotherapy, might indicate thalamocortical dysfunction in schizophrenia.
机译：我们假设精神分裂症中P300异常和脑电图节律失真所反映的认知缺陷可能相互关联，这可能与皮层下生成系统共享。我们的目标是评估精神分裂症患者P300与脑电图节奏产生之间的关系。记录了25名未经药物治疗的患者的静息状态下的定量脑电图（QEEG）和听觉怪胎范例中的P300。此外，使用CT扫描测量部分反映丘脑体积的侧脑室比（LV-BR）。还对简要的精神病评定量表（BPRS）和阴性症状评估量表（SANS）进行了评定。 Pz处的P300幅度与药物治疗前的theta和慢α功率呈正相关，但是，该相关趋势往往限于药物治疗后的快速α。 BPRS和SANS与QEEG无显着相关性。高频段，如快速α和β显示出与LV-BR负相关的趋势。药物治疗前P300振幅与快速α功率之间缺乏相关性（药物治疗后恢复），可能表明精神分裂症的丘脑皮质功能障碍。

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