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首页> 外文期刊>Journal of the American Society of Hypertension : >Apparent treatment-resistant hypertension and risk for stroke, coronary heart disease, and all-cause mortality
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Apparent treatment-resistant hypertension and risk for stroke, coronary heart disease, and all-cause mortality

机译：明显的抗治疗性高血压以及中风，冠心病和全因死亡率的风险

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Apparent treatment-resistant hypertension (aTRH) is defined as uncontrolled hypertension despite the use of three or more antihypertensive medication classes or controlled hypertension while treated with four or more antihypertensive medication classes. We evaluated the association of aTRH with incident stroke, coronary heart disease (CHD), and all-cause mortality. Participants from the population-based REasons for Geographic And Racial Differences in Stroke (REGARDS) Study treated for hypertension with aTRH (n = 2043) and without aTRH (n = 12,479) were included. aTRH was further categorized as controlled aTRH (>= 4 medication classes and controlled hypertension) and uncontrolled aTRH (>= 3 medication classes and uncontrolled hypertension). Over a median of 5.9, 4.4, and 6.0 years of follow-up, the multivariable adjusted hazard ratio for stroke, CHD, and all-cause mortality associated with aTRH versus no aTRH was 1.25 (0.94-1.65), 1.69 (1.27-2.24), and 1.29 (1.14-1.46), respectively. Compared with controlled aTRH, uncontrolled aTRH was associated with CHD (hazard ratio, 2.33; 95% confidence interval, 1.21-4.48), but not stroke or mortality. Comparing controlled aTRH with no aTRH, risk of stroke, CHD, and all-cause mortality was not elevated. aTRH was associated with an increased risk for coronary heart disease and all-cause mortality. (C) 2014 American Society of Hypertension. All rights reserved.
机译：尽管使用三种或三种以上降压药物类别或使用四种或四种以上降压药物类别治疗的受控高血压，但明显的抗治疗性高血压（aTRH）定义为不受控制的高血压。我们评估了aTRH与中风，冠心病（CHD）和全因死亡率的关系。来自以人群为基础的卒中地理和种族差异原因（REGARDS）研究的参与者包括接受aTRH（n = 2043）和未接受aTRH（n = 12,479）治疗的高血压患者。 aTRH进一步分为受控aTRH（> = 4种药物类别和受控高血压）和不受控制的aTRH（> = 3种药物类别和不受控制的高血压）。在5.9、4.4和6.0年的中位数随访中，与aTRH相比无aTRH的中风，CHD和全因死亡率的多变量调整风险比为1.25（0.94-1.65），1.69（1.27-2.24） ）和1.29（1.14-1.46）。与控制aTRH相比，不受控制的aTRH与冠心病相关（危险比2.33; 95％置信区间1.21-4.48），但与卒中或死亡率无关。将对照aTRH与无aTRH进行比较，卒中，冠心病和全因死亡率的风险未升高。 aTRH与冠心病和全因死亡率增加的风险有关。 （C）2014年美国高血压学会。版权所有。

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