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首页> 外文期刊>Journal of the American Society of Nephrology: JASN >Overcoming Barriers in Kidney Health-Forging a Platform for Innovation
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Overcoming Barriers in Kidney Health-Forging a Platform for Innovation

机译：克服肾脏健康的障碍-打造创新平台

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摘要

Innovation in kidney diseases is not commensurate with the effect of these diseases on human health and mortality or innovation in other key therapeutic areas. A primary cause of the dearth in innovation is that kidney diseases disproportionately affect a demographic that is largely disenfranchised, lacking sufficient advocacy, public attention, and funding. A secondary and likely consequent cause is that the existing infrastructure supporting nephrology research pales in comparison with those for other internal medicine specialties, especially cardiology and oncology. Citing such inequities, however, is not enough. Changing the status quo will require a coordinated effort to identify and redress the existing deficits. Specifically, these deficits relate to the need to further develop and improve the following: understanding of the disease mechanisms and pathophysiology, patient engagement and activism, clinical trial infrastructure, and investigational clinical trial designs as well as coordinated efforts among critical stakeholders. This paper identifies potential solutions to these barriers, some of which are already underway through the Kidney Health Initiative. The Kidney Health Initiative is unique and will serve as a current and future platform from which to overcome these barriers to innovation in nephrology.
机译：肾脏疾病的创新与这些疾病对人类健康和死亡率的影响或其他关键治疗领域的创新不相称。缺乏创新的主要原因是肾脏疾病在很大程度上影响了被剥夺权利，缺乏足够的倡导，公众关注和资金支持的人口。第二个可能的结果是，与其他内科专业（尤其是心脏病学和肿瘤学）相比，支持肾脏病研究的现有基础设施显得苍白。但是，仅列举这种不平等现象是不够的。改变现状将需要协调一致的努力，以发现和纠正现有的不足。具体而言，这些缺陷涉及需要进一步发展和改善以下方面：对疾病机理和病理生理学，患者参与和行动，临床试验基础设施和临床试验设计的理解以及关键利益相关者之间的协调努力。本文确定了针对这些障碍的潜在解决方案，其中一些正在通过肾脏健康计划进行中。肾脏健康计划是独一无二的，它将作为当前和未来的平台，从中克服肾病学创新的这些障碍。

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