...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the American Veterinary Medical Association >Analgesic efficacy and respiratory effects of butorphanol and morphine in turtles
【24h】

Analgesic efficacy and respiratory effects of butorphanol and morphine in turtles

机译：布托啡诺和吗啡对海龟的镇痛效果和呼吸作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To test the hypothesis that butorphanol or morphine induces antinociception with minimal respiratory depression in conscious red-eared slider turtles. DESIGN: Prospective crossover study. ANIMALS: 37 adult male and female red-eared slider turtles (Trachemys scripta). PROCEDURES: Antinociception (n = 27 turtles) and respiratory (10 turtles) experiments were performed. Infrared heat stimuli were applied to the plantar surface of turtle limbs. Thermal withdrawal latencies were measured before and at intervals after SC administration of physiologic saline (0.9% NaCl) solution, butorphanol tartrate (2.8 or 28 mg/kg [1.27 or 12.7 mg/lb]), or morphine sulfate (1.5 or 6.5 mg/kg [0.68 or 2.95 mg/lb]). Ventilation was assessed in freely swimming turtles before and after SC administration of saline solution, butorphanol (28 mg/kg), or morphine (1.5 mg/kg). RESULTS: For as long as 24 hours after injection of saline solution or either dose of butorphanol, thermal withdrawal latencies among turtles did not differ. Low- and high-dose morphine injections increased latencies significantly by 8 hours. Ventilation was not altered by saline solution administration, was temporarily depressed by 56% to 60% for 1 to 2 hours by butorphanol (28 mg/kg) administration, and was significantly depressed by a maximum of 83 +/- 9% at 3 hours after morphine (1.5 mg/kg) injection. Butorphanol and morphine depressed ventilation by decreasing breathing frequency. CONCLUSIONS AND CLINICAL RELEVANCE: Although widely used in reptile species, butorphanol may not provide adequate antinociception for invasive procedures and caused short-term respiratory depression in red-eared slider turtles. In contrast, morphine apparently provided antinociception but caused long-lasting respiratory depression.
机译：目的：检验在有意识的红耳滑龟中丁苯啡诺或吗啡能诱导镇痛作用，并使呼吸抑制作用降至最低的假设。设计：前瞻性交叉研究。动物：37只成年男性和女性红耳滑龟（Trachemys scripta）。程序：进行了抗伤害感受（n = 27只海龟）和呼吸（10只海龟）实验。将红外热刺激施加到turtle肢的足底表面。在SC施用生理盐水（0.9％NaCl）溶液，酒石酸丁啡烷酯（2.8或28 mg / kg [1.27或12.7 mg / lb]）或硫酸吗啡（1.5或6.5 mg / lb）之前和之后间隔测量热撤回潜伏期公斤[0.68或2.95毫克/磅]。在SC注射盐溶液，丁苯啡诺（28 mg / kg）或吗啡（1.5 mg / kg）之前和之后，对自由游泳的海龟进行通风评估。结果：注射盐溶液或两种剂量的布托啡诺后长达24小时，海龟之间的热退缩潜伏期没有差异。小剂量和大剂量吗啡注射可使潜伏期显着增加8小时。给予盐溶液不会改变通气，但给予丁啡诺（28 mg / kg）可使通气暂时降低56％至60％1至2小时，并于3小时显着降低最大83 +/- 9％吗啡（1.5 mg / kg）注射后。布托啡诺和吗啡通过降低呼吸频率来抑制通气。结论和临床意义：尽管丁烷醇在爬行动物中广泛使用，但可能无法为侵入性操作提供足够的抗伤害感受，并可能导致红耳滑龟短期呼吸抑制。相反，吗啡显然具有抗伤害作用，但会导致长期的呼吸抑制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号