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首页> 外文期刊>Journal of the American Veterinary Medical Association >Water-flow variation and pharmacoepidemiology of tetracycline hydrochloride administration via drinking water in swine finishing farms
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Water-flow variation and pharmacoepidemiology of tetracycline hydrochloride administration via drinking water in swine finishing farms

机译：养猪场饮水中四环素盐酸盐的水流量变化和药物流行病学

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Objective--To evaluate variation of drinking-water flow rates in swine finishing barns and the relationship between drinker flow rate and plasma tetracycline concentrations in pigs housed in different pens. Design--Cross-sectional (phase 1) and cohort(phase 2) studies. Sample Population--13 swine finishing farms (100 barns with 7,122 drinkers) in phase 1 and 100 finishing-stage pigs on 2 finishing farms (1 barn/farm) in phase 2. Procedures--In phase 1, farms were evaluated for water-flow variation,taking into account the following variables: position of drinkers within the barn, type of drinker (swing or mounted), pig medication status, existence of designated sick pen, and existence of leakage from the waterline. In phase 2, blood samples were collected from 50 pigs/barn (40 healthy and 10 sick pigs) in 2 farms at 0, 4, 8, 24, 48, and 72 hours after initiation of water-administered tetracycline HCI (estimated dosage, 22 mg/kg [10 mg/lb]). Plasma tetracycline concentrations were measured via ultraperformance liquid chromatography. Results--Mean farm drinker flow rates ranged from 1.44 to 2.77 L/min. Significant differences in flow rates existed according to drinker type and whether tetracycline was included in the water. Mean drinker flow ratesand plasma tetracycline concentrations were significantly different between the 2 farms but were not different between healthy and sick pigs. The plasma tetracycline concentrations were typically < 0.3 mu g/mL. Conclusions and Clinical Relevance--Many factors affected drinker flow rates and therefore the amount of medication pigs might have received. Medication of pigs with tetracycline through water as performed in this study had questionable therapeutic value.
机译：目的-评估猪舍中不同猪圈的饮用水流量的变化以及饮水流量与血浆四环素浓度之间的关系。设计-横断面（阶段1）和队列（阶段2）研究。第1阶段的人口-13猪场肥育场（100个畜棚，有7,122名饮水器），第2阶段的2个肥育场（1个猪场/农场）中有100头肥育阶段猪。 -流量变化，考虑以下变量：饮水器在畜舍内的位置，饮水器的类型（摆动或悬挂式），生猪用药状态，指定病笔的存在和水线泄漏的存在。在第2阶段，在开始施用水四环素HCl（估算剂量，0,4,8,24,48和72小时）后，从2个农场的50头猪/仓（40头健康的猪和10头有病的猪）中采集了血样。 22 mg / kg [10 mg / lb]）。通过超高效液相色谱法测定血浆四环素浓度。结果-农场饮水器的平均流量为1.44至2.77 L / min。根据饮水器类型以及水中是否包含四环素，流速存在显着差异。在这两个农场之间，饮酒者的平均饮水率和血浆四环素浓度有显着差异，但健康猪和病猪之间没有差异。血浆四环素浓度通常<0.3μg / mL。结论和临床意义-许多因素影响饮水器的流量，因此可能会影响猪的用药量。在这项研究中通过水对四环素进行猪的药物治疗具有可疑的治疗价值。

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