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首页> 外文期刊>Clinical drug investigation >Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen
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Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen

机译：通过利多卡因和/或氟比洛芬的预处理减少异丙酚引起的疼痛

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Objective: Pain is a well recognised complication of propofol injection. The purpose of this study was to compare the efficacy of flurbiprofen, lidocaine and a combination of the two in reducing pain on injection of propofol. Design: Prospective, randomised, double-blind, placebo-controlled study. Setting: University hospital in Tsukuba City, Japan.Patients and interventions: 120 patients, 56 males and 64 females, aged 20-66 years, scheduled for elective plastic surgery were included. Patients received intravenously either lidocaine 20mg, flurbiprofen 50mg, both, or placebo (saline) accompanied by manual venous occlusion for 2 minutes, followed by administration of propofol 2 mg/kg into a dorsal hand vein (n = 30 in each group). A blinded researcher asked each patient to evaluate the pain score (0 = none, 1 = mild, 2 = moderate, 3 = severe) during propofol injection.Main outcome measures and results: The incidence and intensity of pain was less in patients receiving lidocaine (27%, pain score 0 [median]), flurbiprofen (43%, 0), or both (3%, 0) along with venous occlusion than in those receiving placebo (90%, 2) along with venous occlusion (p < 0.01). Combined lidocaine and flurbiprofen with venous occlusion was the most effective treatment (p < 0.05). No complications such as pain, oedema, wheal or flare response were observed at the injection sites within the first 24 hours after surgery. Conclusion: Combined lidocaine 20mg and flurbiprofen 50mg along with venous occlusion for 2 minutes was very effective for reducing pain on injection of propofol in patients scheduled for elective plastic surgery.
机译：目的：疼痛是公认的丙泊酚注射液并发症。这项研究的目的是比较氟比洛芬，利多卡因和两者的组合在减轻异丙酚注射时的疼痛中的功效。设计：前瞻性，随机，双盲，安慰剂对照研究。地点：日本筑波市的大学医院，患者和干预措施：包括计划进行择期整形手术的120例患者，男56例，女64例，年龄20-66岁。患者静脉注射利多卡因20mg，氟比洛芬50mg（两者）或安慰剂（盐水），并手动静脉闭塞2分钟，然后向手背静脉给予异丙酚2 mg / kg（每组n = 30）。盲人研究者要求每位患者评估异丙酚注射过程中的疼痛评分（0 =无，1 =轻度，2 =中度，3 =严重）。主要预后指标和结果：利多卡因患者的疼痛发生率和强度较低（27％，疼痛评分0 [中位数]），氟比洛芬（43％，0）或两者（3％，0）与静脉阻塞相比，与接受安慰剂和静脉阻塞的患者（90％，2）（p < 0.01）。利多卡因和氟比洛芬联合静脉阻塞是最有效的治疗方法（p <0.05）。在手术后的最初24小时内，在注射部位未观察到诸如疼痛，水肿，风疹或耀斑反应等并发症。结论：利多卡因20mg和氟比洛芬50mg联合静脉阻塞2分钟，对于计划进行择期整形手术的患者，在注射异丙酚时可有效减轻疼痛。

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