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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >EEG correlates of startle reflex with reactivity to eye opening in psychiatric disorders: preliminary results.
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EEG correlates of startle reflex with reactivity to eye opening in psychiatric disorders: preliminary results.

机译：脑电图惊吓反射与精神病患者睁眼的反应性相关：初步结果。

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摘要

Previous studies have shown alterations of eyeblink reflex in patients with various psychiatric disorders. It has previously been demonstrated by our group that EEG measures of the reactivity to eye opening could effectively predict patient-reported startle response in patients with acute stress reaction. In our present study, EEG spectral power analysis and eyeblink electrical startle responses were acquired from a total of 39 patients diagnosed with various psychiatric disorders: 7 patients with schizophrenia, 10 patients with major depressive disorder (MDD), 10 patients with panic disorder, 5 patients with posttraumatic stress disorder (PTSD) and 7 patients with generalized anxiety disorder (GAD). EEG percent power data of each frequency band (delta, theta, alpha, beta) obtained from the 19 leads under open or closed eyelid conditions were used to calculate the arithmetical difference between eyes-open and eyes-closed states as representative of "EEG reactivity to eye opening". Data was analyzed separately for each diagnostic group. For all of the disorders, right-sided R2c (contralateral secondary component) latency was the single eyeblink startle measure that was found to be significantly correlated with EEG reactivity to eye opening. The correlation was most significant for right temporal theta frequency in schizophrenia, right temporal theta frequency in MDD, left central beta frequency in panic disorder, left parietotemporal delta frequency in PTSD and right occipital alpha frequency in GAD. Findings showed a newly identified pattern that has potential scientific and clinical value with respect to psychiatric medicine.
机译：先前的研究表明患有各种精神疾病的患者的眨眼反射改变。我们的研究小组先前已经证明，EEG对睁眼反应的测量可以有效预测急性应激反应患者的惊吓反应。在本研究中，从诊断为各种精神疾病的39例患者中获得了EEG频谱功率分析和眨眼电惊反应：7例精神分裂症患者，10例重度抑郁症（MDD），10例恐慌症，5创伤后应激障碍（PTSD）患者和7例广泛性焦虑症（GAD）患者。在睁开或闭合眼睑条件下，从19条导联获得的每个频带（δ，θ，α，β）的EEG百分比功率数据用于计算睁眼和闭眼状态之间的算术差，以代表“ EEG反应性”开眼界”。每个诊断组分别分析数据。对于所有这些疾病，右侧R2c（对侧次要成分）潜伏期是单次眨眼惊吓的量度，被发现与EEG对睁眼的反应性显着相关。相关性对于精神分裂症中的右颞θ频率，MDD中的右颞θ频率，惊恐症中的左中β频率，PTSD中的左顶颞颞角频率以及GAD中的右枕α频率最为相关。研究结果表明，新发现的模式在精神医学方面具有潜在的科学和临床价值。

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