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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Alzheimer disease: caused by primary deficiency of the cerebral blood flow.
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Alzheimer disease: caused by primary deficiency of the cerebral blood flow.

机译：阿尔茨海默氏病：由脑血流的主要缺乏引起。

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摘要

Alzheimer's disease (AD) is associated with considerably decreased cerebral blood flow (CBF) thought to be secondary, since dead neurons do not need oxygen and glucose. This view, however, needs to be critically re-examined. The role of CBF in AD was submitted to a thorough analysis, raising the question: "Is there really a lack of demand in the presence of undisturbed blood supply?" CBF decline is present in AD while the number of affected CNS systems is still quite small. The step-by-step evolution of AD mirrors a brain that progressively becomes ischemic. Areas related to memory function (hippocampus, temporal lobe cortex and vicinity) are bound to suffer first because of their particularly vulnerable blood supply. This is the scenario of a disorder caused by primary and not by secondary CBF deficiency--a deficiency perhaps attributable to the upright gait of homo sapiens. This new approach also opens new avenues for treatment and prevention, which will be briefly discussed.
机译：阿尔茨海默氏病（AD）与被认为是继发性的脑血流量（CBF）大大降低有关，因为死亡的神经元不需要氧气和葡萄糖。但是，必须严格地重新审查这种观点。对CBF在AD中的作用进行了彻底的分析，提出了一个问题：“在血液供应不受干扰的情况下，需求真的不足吗？” AD中存在CBF下降，而受影响的CNS系统的数量仍然很小。 AD的逐步演变反映了逐渐变得缺血的大脑。与记忆功能有关的区域（海马，颞叶皮层及其附近区域）必定首先遭受苦难，因为它们的血液供应特别脆弱。这是由原发性CBF缺乏而不是继发性CBF缺乏引起的疾病-这种缺陷可能归因于智人的直立步态。这种新方法也为治疗和预防开辟了新途径，将对此进行简要讨论。

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