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Challenge tests of monoaminergic systems: neurophysiological aspects.

机译:单胺能系统的挑战测试:神经生理学方面。

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摘要

Monoaminergic challenge tests allow investigating central nervous changes in humans under acute depletion of specific neurotransmitters (5-HT, DA, NE). Along with studies using alpha-methyl-para-tyrosine test (AMPT) and phenylalanine/tyrosine depletion test (APTD), the tryptophan depletion test (ATDT) represents the currently most established human challenge tool for the assessment of brain serotonin functioning. Neurophysiological studies in healthy and clinical samples may contribute to the search for a non-invasive and reliable biological marker of monoaminergic vulnerability or dysfunction. In the design of these studies, various biochemical and methodological aspects have to be taken into account. This article focuses on electrophysiological methodology and results of monoamine depletion studies (i.e., electroencephalography, magnetoencephalography, polysomnography, auditory evoked potentials and startle response).
机译:单胺能激发试验可以研究在特定神经递质(5-HT,DA,NE)急性消耗下人的中枢神经变化。除了使用α-甲基-对-酪氨酸试验(AMPT)和苯丙氨酸/酪氨酸耗竭试验(APTD)的研究外,色氨酸耗竭试验(ATDT)代表了目前最成熟的人类挑战工具,用于评估脑5-羟色胺功能。在健康和临床样本中进行神经生理学研究可能有助于寻找单胺能脆弱性或功能障碍的非侵入性和可靠的生物学标记。在设计这些研究时,必须考虑各种生化和方法学方面。本文重点介绍电生理学方法和单胺耗竭研究的结果(即脑电图,磁脑电图,多导睡眠图,听觉诱发电位和惊吓反应)。

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