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首页> 外文期刊>Journal of the American Academy of Child and Adolescent Psychiatry >Familial clustering of executive functioning in affected sibling pair families with ADHD.
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Familial clustering of executive functioning in affected sibling pair families with ADHD.

机译：在患有多动症的受影响同胞对家庭中执行功能的家族聚类。

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OBJECTIVE: To investigate familial clustering of executive functioning (i.e., response inhibition, fine visuomotor functioning, and attentional control) in attention-deficit/hyperactivity disorder (ADHD)-affected sibling pairs. METHOD: Fifty-two affected sibling pairs aged 6 to 18 years and diagnosed with ADHD according to DSM-IV performed the Stroop test, goo-go task, two different fine visuomotor tracking tasks, and a sustained-, divided-, and focused attention task. RESULTS: Significant correlations (r = 0.4) were found between siblings for response inhibition and attentional control and for fine visuomotor skills that made high demands on executive functioning. CONCLUSIONS: Response inhibition, higher order controlled fine visuomotor functioning, and attentional control seem to cluster in ADHD-affected siblings. This suggests that these aspects of executive dysfunctioning may reflect an endophenotype of ADHD. Measurement of these executive functions may facilitate the identification of genes involved in ADHD by forming more homogeneous subgroups.
机译：目的：研究在注意力缺陷/多动障碍（ADHD）影响的同胞对中执行功能的家族聚类（即反应抑制，良好的视觉运动功能和注意控制）。方法：对52名年龄在6至18岁并根据DSM-IV诊断为ADHD的同胞兄弟姐妹进行了Stroop测试，执行/不执行任务，两项不同的视觉运动跟踪任务以及持续的，分开的和集中注意力的任务。结果：在兄弟姐妹之间发现显着相关性（r = 0.4），用于抑制反应和注意控制以及对执行功能有很高要求的精细的视运动技能。结论：反应抑制，较高阶的精细视觉运动功能和注意力控制似乎集中在受ADHD影响的兄弟姐妹中。这表明执行功能障碍的这些方面可能反映了ADHD的内表型。这些执行功能的测量可通过形成更均一的亚组来促进与ADHD有关的基因的鉴定。

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