...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the American Academy of Child and Adolescent Psychiatry >Neuropsychiatric disorders associated with streptococcal infection: a case-control study among privately insured children.
【24h】

Neuropsychiatric disorders associated with streptococcal infection: a case-control study among privately insured children.

机译：与链球菌感染有关的神经精神疾病：一项有私人保险的儿童的病例对照研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE:: To assess whether antecedent streptococcal infection(s) increase the risk of subsequent diagnosis of obsessive-compulsive disorder (OCD), Tourette syndrome (TS), other tic disorders, attention-deficit/hyperactivity disorder (ADHD), or major depressive disorder (MDD) in a national sample of privately insured children. METHOD:: Using health insurance claims data, we compared the prior year's occurrence of streptococcal infection in children ages 4 to 13 years with OCD, TS, or tic disorder newly diagnosed between January 1998 and December 2004 to that of a cohort of matched controls. Conditional logistic regression models were used to determine the association of prior streptococcal sore throat or scarlet fever with a diagnosis of OCD, TS, or tic disorder. We repeated the analyses for two other infectious diseases (otitis media and sinusitis) and one noninfectious condition (migraine). We also investigated the potential specificity of this association by performing similar analyses focused on newly diagnosed ADHD and newly diagnosed MDD. RESULTS:: Subjects with newly diagnosed OCD, TS, or tic disorder were more likely than controls to have had a diagnosis of streptococcal infection in the previous year (odds ratio 1.54, 95% confidence interval 1.29-2.15). Prior streptococcal infection was also associated with incident diagnoses of ADHD (odds ratio 1.20, 95% confidence interval 1.06-1.35) and MDD (odds ratio 1.63, 95% confidence interval 1.12-2.30). CONCLUSIONS:: These findings provide epidemiologic evidence that some pediatric-onset neuropsychiatric disorders, including OCD, tic disorders, ADHD, and MDD, may be temporally related to prior streptococcal infections. Whether this is the result of a nonspecific stress response or secondary to an activation of the immune system remains to be determined.
机译：目的：评估以前的链球菌感染是否会增加随后诊断为强迫症（OCD），图雷特综合征（TS），其他抽动症，注意力缺陷/多动症（ADHD）或重度抑郁症的风险全国有私人参保的儿童样本中的儿童疾病（MDD）。方法：使用健康保险理赔数据，我们比较了1998年1月至2004年12月间新诊断出的患有OCD，TS或抽动障碍的4至13岁儿童中前一年链球菌感染的发生率，并与对照组进行了比较。使用条件逻辑回归模型确定先前的链球菌性咽喉炎或猩红热与OCD，TS或抽动障碍的诊断之间的关系。我们对其他两种传染病（中耳炎和鼻窦炎）和一种非传染病（偏头痛）重复了分析。我们还通过针对新诊断的ADHD和新诊断的MDD进行了类似的分析，研究了这种关联的潜在特异性。结果：新诊断为OCD，TS或抽动障碍的受试者比上一年被诊断出链球菌感染的可能性更高（优势比1.54，95％置信区间1.29-2.15）。先前的链球菌感染还与多动症（优势比1.20，95％置信区间1.06-1.35）和MDD（优势比1.63，95％置信区间1.12-2.30）的事件诊断有关。结论：这些发现提供了流行病学证据，包括OCD，抽动障碍，ADHD和MDD的一些小儿发作性神经精神疾病可能与先前的链球菌感染在时间上相关。这是否是非特异性应激反应的结果还是免疫系统激活的继发结果尚待确定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号