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首页> 外文期刊>Journal of the American Academy of Child and Adolescent Psychiatry >CBCL Pediatric Bipolar Disorder Profile and ADHD: Comorbidity and Quantitative Trait Loci Analysis.
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CBCL Pediatric Bipolar Disorder Profile and ADHD: Comorbidity and Quantitative Trait Loci Analysis.

机译：CBCL小儿双相情感障碍和多动症：合并症和定量性状位点分析。

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OBJECTIVE:: The pediatric bipolar disorder profilme of the Child Behavior Checklist (CBCL-PBD), a parent-completed measure that avoids clinician ideological bias, has proven useful in differentiating patients with attention-deficit/hyperactivity disorder (ADHD). We used CBCL-PBD profiles to distinguish patterns of comorbidity and to search for quantitative trait loci in a genomewide scan in a sample of multiple affected ADHD sibling pairs. METHOD:: A total of 540 ADHD subjects ages 5 to 18 years were assessed with the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version and CBCL. Parents were assessed with the Schedule for Affective Disorders and Schizophrenia-Lifetime version supplemented by the Schedule for Affective Disorders and Schizophrenia for School-Age Children for disruptive behavioral disorders. Patterns of psychiatric comorbidity were contrasted based on the CBCL-PBD profile. A quantitative trait loci variance component analysis was used to identify potential genomic regions that may harbor susceptibility genes for the CBCL-PBD quantitative phenotype. RESULTS:: Bipolar spectrum disorders represented less than 2% of the overall sample. The CBCL-PBD classification was associated with increased generalized anxiety disorder (p =.001), oppositional defiant disorder (p =.008), conduct disorder (p =.003), and parental substance abuse (p =.005). A moderately significant linkage signal (multipoint maximum lod score = 2.5) was found on chromosome 2q. CONCLUSIONS:: The CBCL-PBD profile distinguishes a subset of ADHD patients with significant comorbidity. Linkage analysis of the CBCL-PBD phenotype suggests certain genomic regions that merit further investigation for genes predisposing to severe psychopathology.
机译：目的：儿童行为检查表（CBCL-PBD）的小儿双相情感障碍病原体是一项由家长完成的避免临床医生意识形态偏见的措施，已被证明可用于区分注意力缺陷多动障碍（ADHD）患者。我们使用CBCL-PBD配置文件来区分合并症模式，并在多个受影响的ADHD同胞对样本中进行全基因组扫描，以寻找定量性状基因座。方法：对540名5至18岁的ADHD受试者进行了评估，包括《学龄儿童及终生版情感障碍和精神分裂症的时间表》以及CBCL。父母接受了《情感障碍时间表》和《精神分裂症终生版》，并补充了《情感障碍时间表》和《学龄儿童精神分裂症》中有关破坏性行为障碍的表。根据CBCL-PBD资料对比了精神病合并症的模式。定量性状基因座方差成分分析用于确定可能包含CBCL-PBD定量表型易感基因的潜在基因组区域。结果：双极谱障碍占不到总样本的2％。 CBCL-PBD分类与广泛性焦虑症（p = .001），对立违抗性障碍（p = .008），品行障碍（p = .003）和父母滥用药物（p = .005）有关。在染色体2q上发现了中等显着的连锁信号（多点最大lod得分= 2.5）。结论：CBCL-PBD谱区分具有明显合并症的多动症患者。 CBCL-PBD表型的连锁分析表明，某些基因组区域值得进一步研究易患严重精神病理学的基因。

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