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首页> 外文期刊>Journal of the American Academy of Child and Adolescent Psychiatry >Structure of the autism symptom phenotype: A proposed multidimensional model.
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Structure of the autism symptom phenotype: A proposed multidimensional model.

机译：自闭症症状表型的结构：提出的多维模型。

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BACKGROUND: The main objective of this study was to develop a comprehensive, empirical model that will allow the reorganization of the structure of the pervasive developmental disorder symptom phenotype through factor analysis into more homogeneous dimensions. METHOD: The sample consisted of 209 children with pervasive developmental disorder referred for genetic studies. The 12 subdomains of the Autism Diagnostic Interview-Revised were used in a factor analysis, and the emerged factors were then correlated with independent variables (measures of cognition, adaptive function, and diagnostic subtype). Intraclass correlation coefficients were calculated to investigate any familial relationships between sibling pairs on the derived factors. RESULTS: The autism symptom phenotype is indeed made up of three factors or domains that are somewhat different than those used in DSM-IV. Rather, domains include social-communication, inflexible language and behavior, and repetitive sensory and motor behavior. For the three factors, only a small amount of variance was accounted for by cognitive and adaptive functioning. Only inflexible language and behavior showed familial correlation between siblings. CONCLUSIONS: The pervasive developmental disorder symptom phenotype is composed of three domains or factors: social-communication, inflexible language and behavior, and repetitive sensory and motor behavior. Each child with pervasive developmental disorder can be characterized by these dimensions, which give an informative picture of the clinical presentation and a quantitative estimate of the severity of the disability.
机译：背景：本研究的主要目的是建立一个全面的经验模型，该模型将通过因素分析将普遍性发育障碍症状表型的结构重组为更均一的维度。方法：该样本由209名广泛性发育障碍儿童组成，用于基因研究。自闭症诊断访谈修订版的12个子域用于因子分析，然后将出现的因子与独立变量（认知措施，适应功能和诊断亚型）相关联。计算类内相关系数以调查在衍生因子上兄弟对之间的任何家族关系。结果：自闭症症状表型的确由与DSM-IV中使用的三个因素或域略有不同的三个因素或域组成。相反，领域包括社交交流，不灵活的语言和行为，以及重复的感觉和运动行为。对于这三个因素，认知和适应功能仅占很小的差异。只有不灵活的语言和行为表现出兄弟姐妹之间的家族关系。结论：普遍性发育障碍症状表型由三个领域或因素组成：社交交流，僵化的语言和行为以及重复的感觉和运动行为。每个患广泛性发育障碍的孩子都可以通过这些维度来表征，这些维度可以提供临床表现的丰富信息，并提供残疾严重程度的定量估计。

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