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首页> 外文期刊>Journal of the American Academy of Child and Adolescent Psychiatry >Abnormal functional activation and connectivity in the working memory network in early-onset schizophrenia
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Abnormal functional activation and connectivity in the working memory network in early-onset schizophrenia

机译：早期精神分裂症工作记忆网络中的异常功能激活和连通性

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Disruption within the working memory (WM) neural network is considered an integral feature of schizophrenia. The WM network, and the dorsolateral prefrontal cortex (DLPFC) in particular, undergo significant remodeling in late adolescence. Potential interactions between developmental changes in the WM network and disease-related processes for schizophrenia remain unclear. The aim of this study was to determine whether DLPFC activation and functional connectivity are impaired during WM in patients with early-onset schizophrenia (EOS; age of onset <18 years). We used functional magnetic resonance imaging and psychophysiological interaction analysis to respectively measure blood oxygenation leveldependent signal and to derive functional connectivity estimates in response to the two-back WM task from 25 youths with EOS and 20 matched healthy adolescents. Compared with healthy adolescents, patients with EOS showed reduced engagement of the DLPFC, the anterior cingulate cortex (ACC), and frontal operculum, and had reduced DLPFC connectivity within the WM network. Patients with EOS showed abnormal reduction in the coupling of the DLPFC with the ACC, the inferior parietal lobule, and the middle occipital gyrus. In contrast to healthy adolescents, patients with EOS expressed age-related decrease in the activity of the DLPFC and an increase in its connectivity with the ACC. Patients with EOS show dysfunctional engagement and reduced integration within the WM neural network. The pattern of abnormal age-related correlations in DLPFC activity and connectivity suggests that schizophrenia-related processes have an impact on brain regions that show significant late developmental changes.
机译：工作记忆（WM）神经网络中的中断被认为是精神分裂症的重要特征。 WM网络，尤其是背外侧前额叶皮层（DLPFC），在青春期后期经历了重大的重塑。 WM网络的发展变化与精神分裂症的疾病相关过程之间的潜在相互作用仍然不清楚。这项研究的目的是确定早发性精神分裂症（EOS;起病年龄<18岁）的患者在WM期间DLPFC激活和功能连接性是否受损。我们使用功能磁共振成像和心理生理学相互作用分析分别测量了血液氧合水平依赖性信号，并根据25名EOS青年和20名健康青少年的双向WM任务得出了功能连通性估算值。与健康的青少年相比，患有EOS的患者表现出DLPFC，前扣带回皮质（ACC）和额盖的参与减少，并且WM网络内的DLPFC连接性降低。 EOS患者显示DLPFC与ACC，顶下小叶和枕中中回的耦合异常减少。与健康的青少年相比，患有EOS的患者表现出与年龄相关的DLPFC活性下降以及与ACC的连通性增加。患有EOS的患者表现出机能障碍，并且在WM神经网络中的整合度降低。 DLPFC活动和连通性中与年龄相关的异常相关模式表明，精神分裂症相关的过程会对大脑区域产生影响，大脑区域显示出显着的晚期发育变化。

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