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首页> 外文期刊>Journal of the American Academy of Dermatology >A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics.
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A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics.

机译：新的美国皮肤鳞状细胞癌癌症分期联合委员会：建立肿瘤（T）特征的依据。

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摘要

BACKGROUND: The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing. Although most patients achieve complete remission with surgical treatment, those with advanced disease have a poor prognosis. The American Joint Committee on Cancer (AJCC) is responsible for the staging criteria for all cancers. For the past 20 years, the AJCC cancer staging manual has grouped all nonmelanoma skin cancers, including cSCC, together for the purposes of staging. However, based on new evidence, the AJCC has determined that cSCC should have a separate staging system in the 7th edition AJCC staging manual. OBJECTIVE: We sought to present the rationale for and characteristics of the new AJCC staging system specific to cSCC tumor characteristics (T). METHODS: The Nonmelanoma Skin Cancer Task Force of AJCC reviewed relevant data and reached expert consensus in creating the 7th edition AJCC staging system for cSCC. Emphasis was placed on prospectively accumulated data and multivariate analyses. Concordance with head and neck cancer staging system was also achieved. RESULTS: A new AJCC cSCC T classification is presented. The T classification is determined by tumor diameter, invasion into cranial bone, and high-risk features, including anatomic location, tumor thickness and level, differentiation, and perineural invasion. LIMITATIONS: The data available for analysis are still suboptimal, with limited prospective outcomes trials and few multivariate analyses. CONCLUSIONS: The new AJCC staging system for cSCC incorporates tumor-specific (T) staging features and will encourage coordinated, consistent collection of data that will be the basis of improved prognostic systems in the future.
机译：背景：皮肤鳞状细胞癌（cSCC）的发病率正在增加。尽管大多数患者可通过手术治疗完全缓解，但那些患有晚期疾病的患者预后较差。美国癌症联合委员会（AJCC）负责所有癌症的分期标准。在过去的20年中，AJCC癌症分期手册将所有非黑色素瘤皮肤癌（包括cSCC）归为一类。但是，根据新的证据，AJCC已在第7版AJCC分期手册中确定cSCC应该具有单独的分期系统。目的：我们试图介绍针对cSCC肿瘤特征（T）的新型AJCC分期系统的原理和特征。方法：AJCC的非黑素瘤皮肤癌特别工作组审查了相关数据，并在建立第7版cSCC的AJCC分期系统方面达成了专家共识。重点放在预期积累的数据和多元分析上。还实现了与头颈癌分期系统的一致性。结果：提出了一种新的AJCC cSCC T分类。 T分类由肿瘤直径，侵入颅骨和高风险特征（包括解剖位置，肿瘤厚度和水平，分化和神经周围侵犯）决定。局限性：可用于分析的数据仍然不是最佳的，前瞻性结果试验有限，多元分析很少。结论：新的用于cSCC的AJCC分期系统结合了肿瘤特异性（T）分期功能，将促进协调一致的数据收集，这将成为未来改善预后系统的基础。

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