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首页> 外文期刊>Journal of the American Academy of Dermatology >Clinicopathologic features and survival in Spitzoid malignant melanoma and conventional malignant melanoma
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Clinicopathologic features and survival in Spitzoid malignant melanoma and conventional malignant melanoma

机译：Spitzoid恶性黑色素瘤和常规恶性黑色素瘤的临床病理特征和生存

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Background Although recent advances in genetics have revealed distinct mutational profiles and molecular signaling pathways associated with Spitzoid malignant melanoma (SMM), less is known about the clinicopathologic characteristics and behavior of SMM compared with conventional melanoma. Objective We sought to determine the clinicopathologic characteristics and mortality risk associated with SMM and conventional malignant melanoma. Methods We conducted a retrospective study of 30 patients with SMM and 30 patients with conventional melanoma. The two groups were matched by age, gender, and depth of tumor invasion. Additional patient- and tumor-level characteristics were compared between groups and regression modeling was used to assess relative mortality risk. Results Unadjusted analyses of SMM and conventional malignant melanoma revealed no significant differences in clinical impression, anatomic location, mitotic rate, and presence of ulceration. Sentinel lymph node biopsy, completion lymphadenectomy, and visceral metastases did not differ between groups. Cox proportional hazards regression showed no differences in mortality between Spitzoid and conventional melanoma. Limitations Small sample size, short follow-up duration, and residual confounding may limit the accuracy and generalizability of our results. Conclusions SMM and conventional malignant melanoma differ in some clinicopathologic features. We did not find a statistically significant difference in mortality between the two.
机译：背景技术尽管遗传学的最新进展揭示了与Spitzoid恶性黑色素瘤（SMM）相关的独特的突变谱和分子信号通路，但与常规黑色素瘤相比，人们对SMM的临床病理特征和行为了解较少。目的我们试图确定与SMM和常规恶性黑色素瘤相关的临床病理特征和死亡风险。方法我们对30例SMM和30例常规黑色素瘤患者进行了回顾性研究。两组按年龄，性别和肿瘤浸润深度进行匹配。在各组之间比较了其他患者和肿瘤水平的特征，并使用回归模型评估相对死亡风险。结果未经调整的SMM和常规恶性黑色素瘤分析显示，在临床印象，解剖位置，有丝分裂率和溃疡存在方面无显着差异。前哨淋巴结活检，完成淋巴结清扫术和内脏转移在两组之间没有差异。 Cox比例风险回归显示Spitzoid和常规黑色素瘤的死亡率无差异。局限性样本量小，随访时间短和残留的混杂物可能会限制我们结果的准确性和推广性。结论SMM和常规恶性黑色素瘤在某些临床病理特征上存在差异。我们没有发现两者之间的死亡率有统计学上的显着差异。

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