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首页> 外文期刊>Journal of the American Academy of Nurse Practitioners. >Probiotics for prevention of antibiotic-associated diarrhea and Clostridium difficile-associated disease in hospitalized adults--a meta-analysis.
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Probiotics for prevention of antibiotic-associated diarrhea and Clostridium difficile-associated disease in hospitalized adults--a meta-analysis.

机译：益生菌预防住院成人抗生素相关性腹泻和艰难梭菌相关疾病的荟萃分析。

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PURPOSE: A serious complication associated with the use of most antibiotics is antibiotic-associated diarrhea (AAD). The purpose of this article is to report findings from a meta-analysis of available studies on adult hospitalized populations to evaluate efficacy of probiotics for prevention of AAD and Clostridium difficile-associated disease (CDAD). DATA SOURCES: A comprehensive, systematic search was conducted to identify all relevant studies on probiotic efficacy for prevention of AAD and CDAD. Data synthesis was done using MAStARI software from the Joanna Briggs Institute (University of Adelaide, Australia). CONCLUSIONS: AAD affects one in five people on antibiotics. Risk factors for the development of AAD include the use of broad-spectrum antibiotics and host factors such as age, health status, hospitalization status, and exposure to nosocomial pathogens. About a third of AAD cases have CDAD. Meta-analysis showed that administration of probiotics led to a statistically significant relative risk reduction of 44% for AAD and 71% for CDAD. IMPLICATIONS FOR PRACTICE: Extended hospital stays, readmissions, and higher hospital costs are just some of the consequences of ADD and CDAD. Strategies currently used include discontinuing or changing the inciting antibiotic, restricting high-risk antibiotics, and encouraging the use of antibiotics based on sensitivity reports. Healthcare spending, morbidity, and mortality can potentially be reduced considerably by reducing the occurrence of ADD and CDAD by administering prophylaxis with probiotics concurrently with antibiotics.
机译：目的：与大多数抗生素相关的严重并发症是抗生素相关性腹泻（AAD）。本文的目的是报告对成人住院人群进行的现有研究的荟萃分析，以评估益生菌预防AAD和艰难梭菌相关疾病（CDAD）的功效。数据来源：进行了全面，系统的搜索，以鉴定有关预防AAD和CDAD的益生菌功效的所有相关研究。使用来自乔安娜·布里格斯学院（澳大利亚阿德莱德大学）的MAStARI软件进行数据合成。结论：AAD影响五分之一的人使用抗生素。发生AAD的危险因素包括使用广谱抗生素和宿主因素，例如年龄，健康状况，住院状况以及暴露于医院病原体。大约三分之一的AAD病例患有CDAD。荟萃分析显示，益生菌的使用在统计学上显着降低了AAD和CDAD的相对危险度，分别为44％和71％。实践的意义：延长住院时间，再入院和更高的医院费用只是ADD和CDAD的部分后果。当前使用的策略包括终止或更改刺激性抗生素，限制高风险抗生素，以及根据敏感性报告鼓励使用抗生素。通过同时使用益生菌和抗生素进行预防，可减少ADD和CDAD的发生，从而可显着降低医疗保健支出，发病率和死亡率。

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