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首页> 外文期刊>Journal of the American Academy of Nurse Practitioners. >Guidance of pharmacotherapy in a complex psychiatric case by CYP450 DNA typing.
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Guidance of pharmacotherapy in a complex psychiatric case by CYP450 DNA typing.

机译：CYP450 DNA分型对复杂精神病患者的药物治疗指导。

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PURPOSE: To illustrate the utility of CYP450 genotyping to guide clinical psychopharmacological treatment decisions and minimize or avoid harmful and costly adverse drug reactions (ADRs). DATA SOURCES: DNA was extracted from a whole blood sample from the case study subject and tested for CYP450 gene polymorphisms in the CLIA certified Laboratory of Personalized Health at Genomas, Inc. Clinical data were obtained from patient records and clinician observations. CONCLUSIONS: We present a case in which the ascertainment of multiple CYP450 isoenzyme deficiencies resulted in a dramatic change in psychotropic treatment approach. Shortly after making these adjustments, the patient saw a significant improvement in most of her debilitating psychiatric symptoms. IMPLICATIONS FOR PRACTICE: In complex cases, CYP450 DNA testing can guide pharmacotherapy by exposing innate hepatic metabolic deficiencies as a result of DNA polymorphism. In such cases, clinicians can favor treatments that target functional isoenzyme pathways rather than deficient or null pathways thus leading to decreased risk of ADRs and improved patient response.
机译：目的：说明CYP450基因分型法可指导临床心理药物治疗决策，并尽量减少或避免有害和昂贵的药物不良反应（ADR）。数据来源：从病例研究对象的全血样本中提取DNA，并在CLIA认证的Genomas，Inc.个性​​化健康实验室中测试CYP450基因多态性。从患者记录和临床观察中获得临床数据。结论：我们提出了一个案例，其中多个CYP450同工酶缺陷的确定导致精神疗法的方法发生了巨大变化。进行这些调整后不久，患者的大部分精神衰弱症状均得到了明显改善。实践的意义：在复杂的情况下，CYP450 DNA检测可以通过暴露因DNA多态性而导致的先天性肝代谢缺陷来指导药物治疗。在这种情况下，临床医生可以选择针对功能同功酶途径而不是不足或无效途径的治疗，从而降低ADR风险并改善患者反应。

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