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首页> 外文期刊>Journal of the American Geriatrics Society >Efficacy and safety of ciprofloxacin oral suspension versus trimethoprim-sulfamethoxazole oral suspension for treatment of older women with acute urinary tract infection.
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Efficacy and safety of ciprofloxacin oral suspension versus trimethoprim-sulfamethoxazole oral suspension for treatment of older women with acute urinary tract infection.

机译：环丙沙星口服混悬液与甲氧苄啶-磺胺甲基异恶唑口服混悬液治疗老年急性尿路感染的疗效和安全性。

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OBJECTIVES: To compare the efficacy and safety of ciprofloxacin (CIP) oral suspension to trimethoprim/sulfamethoxazole (TMP/SMX) oral suspension among older women with acute urinary tract infections (UTIs). DESIGN: Prospective, randomized, open-label, multicenter study of older women (age 65 and older). SETTING: Community and nursing home. PARTICIPANTS: A total of 261 older women were evaluable for safety. Of these, 172 (86 community, 86 nursing home) were evaluable for clinical and bacteriological efficacy. INTERVENTION: Patients were randomized to a 10-day regimen of either CIP (250 mg/5 mL twice daily) or TMP/SMX (160/800 mg/20 mL twice daily). MEASUREMENTS: Clinical response 4 to 10 days posttherapy. RESULTS: For the efficacy-valid population, posttherapy clinical resolution was statistically superior following CIP (97%) versus TMP/SMX (85%) (95% CI=2.0-21.3; P= .009). Eradication of pretreatment bacterial isolates posttherapy was also higher following CIP (95%) versus TMP/SMX (84%) (95% CI=2.7-21.3; P= .019). For the intent-to-treat population, posttherapy clinical resolution was significantly higher in the CIP group (96%) than in the TMP/SMX group (87%) (95% CI=0.2-16.7; P= .025). Safety was assessed in the intent-to-treat population and the incidence of drug-related adverse events were significantly lower following CIP (17%) than following TMP/SMX (27%) (P= .047). Premature discontinuation due to these events was also less prevalent with CIP than with TMP/SMX (2% vs 11%, respectively) (P= .004). CONCLUSION: CIP suspension showed higher clinical success and bacteriological eradication rates than did TMP/SMX for both community-based and nursing home-residing older women with acute UTIs. Furthermore, CIP suspension was associated with significantly lower rates of adverse events and premature discontinuations compared with TMP/SMX suspension.
机译：目的：比较环丙沙星（CIP）口服混悬液与甲氧苄啶/磺胺甲恶唑（TMP / SMX）口服混悬剂在患有急性尿路感染（UTI）的老年妇女中的疗效和安全性。设计：针对年龄较大的女性（65岁及以上）的前瞻性，随机，开放标签，多中心研究。地点：社区和养老院。参与者：共有261名老年妇女的安全性可评估。其中有172个（86个社区，86个疗养院）的临床和细菌学功效可评估。干预：将患者随机分为10天的CIP（250 mg / 5 mL，每天两次）或TMP / SMX（160/800 mg / 20 mL，每天两次）治疗。测量：治疗后4至10天的临床反应。结果：对于有疗效的人群，CIP（97％）后的治疗后临床分辨率在统计学上优于TMP / SMX（85％）（95％CI = 2.0-21.3; P = .009）。与TMP / SMX（84％）（95％CI = 2.7-21.3; P = .019）相比，CIP（95％）后治疗前细菌分离株的根除率也更高。对于意向性治疗人群，CIP组（96％）的治疗后临床分辨率显着高于TMP / SMX组（87％）（95％CI = 0.2-16.7; P = .025）。在意向性治疗人群中评估了安全性，CIP后药物相关不良事件的发生率（17％）显着低于TMP / SMX后（27％）（P = .047）。由这些事件引起的过早停药在CIP中也比在TMP / SMX中少见（分别为2％和11％）（P = .004）。结论：对于以社区为基础和居住在养老院的急性尿路感染的老年妇女，CIP悬浮液的临床成功率和细菌清除率均高于TMP / SMX。此外，与TMP / SMX悬浮液相比，CIP悬浮液与不良事件和过早停药的发生率显着降低。

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