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首页> 外文期刊>Journal of the American Geriatrics Society >Assessing the impact of neuropsychiatric symptoms in Alzheimer's disease: the Neuropsychiatric Inventory Caregiver Distress Scale.
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Assessing the impact of neuropsychiatric symptoms in Alzheimer's disease: the Neuropsychiatric Inventory Caregiver Distress Scale.

机译：评估神经精神症状在阿尔茨海默氏病中的影响：神经精神病目录照料者困扰量表。

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OBJECTIVES: To develop an adjunct scale to the Neuropsychiatric Inventory (NPI) for assessing the impact of neuropsychiatric symptoms in Alzheimer's disease (AD) patients on caregiver distress. DESIGN: Cross-sectional descriptive and correlational study. SETTING: University out-patient memory disorders clinics. PARTICIPANTS: Eighty-five AD subjects and their caregivers (54 spouses, 31 children). MEASUREMENTS: The NPI and NPI Caregiver Distress Scale (NPI-D) were used to assess neuropsychiatric symptoms in AD patients and related caregiver distress, respectively. Criterion validity of the NPI-D was examined (N = 69) by comparison with an abridged version of the Relatives' Stress Scale (RSS'), a general measure of caregiver stress, using item clusters that had previously been correlated to behavioral disturbances in demented patients. Test-retest (n = 20) and inter-rater reliability (n = 16) of the NPI-D were also assessed. RESULTS: Test-retest and interrater reliability of the NPI-D were both adequate. Overall, caregiver NPI-D distress ratings were correlated significantly with the RSS' (r = .60, P < .001). RSS' ratings correlated strongly with NPI scores (r = .64, P < .001), even after controlling for degree of cognitive impairment based on the Mini-Mental State Exam (MMSE) score (r = .61). MMSE scores showed a moderate correlation to RSS' ratings (-.30, P = .02), but this association was markedly attenuated when controlling for the degree of neuropsychiatric disturbance based on the NPI score (r = -. 14). NPI-D ratings for 9 of 10 NPI symptom domains correlated most strongly with either NPI symptom severity or total (frequency x severity) scores. Agitation, dysphoria, irritability, delusions, and apathy were the symptoms most often reported to be severely distressing to caregivers. CONCLUSIONS: The NPI-D provides a reliable and valid measure of subjective caregiver distress in relation to neuropsychiatric symptoms measured by the NPI. Neuropsychiatric alterations are more strongly associated than cognitive symptoms to caregiver distress. The NPI-D may be useful in both clinical and research settings for assessing the contribution to caregiver distress of neuropsychiatric symptoms in AD patients.
机译：目的：制定神经精神病学量表（NPI）的辅助量表，以评估阿尔茨海默病（AD）患者的神经精神病症状对护理人员的困扰。设计：横断面描述性和相关性研究。地点：大学门诊记忆障碍诊所。参与者：85名AD受试者及其照料者（54名配偶，31名儿童）。测量：NPI和NPI照顾者困扰量表（NPI-D）分别用于评估AD患者和相关照顾者困扰的神经精神症状。 NPI-D的标准有效性（N = 69）与相对压力水平量表（RSS'）的简化版进行了比较，RSS'是照料者压力的一种通用量度，使用的是以前与行为障碍相关的项目聚类。痴呆的病人。还评估了NPI-D的重测（n = 20）和评估者间可靠性（n = 16）。结果：NPI-D的重测和间信度均足够。总体而言，照顾者的NPI-D痛苦等级与RSS'显着相关（r = .60，P <.001）。 RSS评分与NPI评分密切相关（r = .64，P <.001），即使在根据小心理状态考试（MMSE）评分控制认知障碍程度之后（r = .61）。 MMSE评分与RSS评分之间呈中等程度的相关性（-.30，P = .02），但是当根据NPI评分控制神经精神疾病的程度时，这种联系会明显减弱（r =-。14）。 10个NPI症状域中的9个的NPI-D评分与NPI症状严重度或总分（频率x严重度）得分之间的相关性最强。躁动，烦躁不安，烦躁不安，妄想和冷漠是最经常报告给护理人员严重困扰的症状。结论：NPI-D提供了一种可靠且有效的方法，用于衡量由NPI测量的与神经精神症状有关的主观照料者的困扰。与护理人员的困扰相比，神经精神方面的变化比认知症状更紧密相关。 NPI-D可能在临床和研究环境中都可用于评估AD患者对神经精神症状的看护困扰的贡献。

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