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首页> 外文期刊>Journal of the American Association for Laboratory Animal Science >Atypical fibrosarcomas derived from cutaneous ganglion cell-like cells in 2 domestic Djungarian hamsters (Phodopus sungorus).
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Atypical fibrosarcomas derived from cutaneous ganglion cell-like cells in 2 domestic Djungarian hamsters (Phodopus sungorus).

机译：非典型纤维肉瘤来源于皮肤的神经节细胞样细胞，来自2只家养的仓鼠（ Phodopus sungorus ）。

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摘要

Androgen-dependent atypical fibromas are benign tumors derived from ganglion-cell-like cells that are particular to Djungarian hamsters (Phodopus sungorus). Masses excised from 2 hamsters were composed of pleomorphic ganglion cell-like cells supported by small to moderate amounts of collagenous matrix. Intracytoplasmic fibrils were present in silver-stained sections, and immunohistochemistry showed that the cells expressed vimentin, androgen receptor, and, in one case, estrogen receptor alpha . In contrast to previously reported atypical fibromas, these tumors had features of anaplasia and were locally invasive. We diagnosed the tumors as atypical fibrosarcomas and consider them an unusual malignant counterpart of atypical fibroma.
机译：雄激素依赖性非典型纤维瘤是源自神经节细胞样细胞的良性肿瘤，这些神经节细胞样细胞是Djungarian仓鼠（ Phodopus sungorus ）特有的。从2只仓鼠切下的肿块由多形性神经节细胞样细胞组成，并由少量至中等量的胶原蛋白基质支持。银染切片中存在胞浆内原纤维，免疫组织化学显示细胞表达波形蛋白，雄激素受体，在一种情况下表达雌激素受体α。与先前报道的非典型纤维瘤相反，这些肿瘤具有发育不全的特征并且是局部浸润性的。我们将肿瘤诊断为非典型纤维肉瘤，并认为它们是非典型纤维瘤的异常恶性。

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