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首页> 外文期刊>Journal of the American Geriatrics Society >Risk and predictors of motor-performance decline in a normally functioning population-based sample of elderly subjects: the Italian Longitudinal Study on Aging.
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Risk and predictors of motor-performance decline in a normally functioning population-based sample of elderly subjects: the Italian Longitudinal Study on Aging.

机译：在正常运行的以人口为基础的老年受试者样本中，运动表现下降的风险和预测指标：意大利纵向老龄化研究。

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OBJECTIVES: To examine risk and predictors of motor-performance (MP) decline targeting subjects performing normally at an initial observation. DESIGN: Cohort study. SETTING: A subsample of the Italian Longitudinal Study on Aging (aged 65-84). PARTICIPANTS: One thousand fifty-two subjects (mean age+/-standard deviation = 71+/-5, 69% men) with normal MP at baseline. MEASUREMENTS: Six tests (standing up from a chair, stepping up, tandem walk, standing on one leg, walking speed, and steps turning 180 degrees ) were used to assess MP at baseline and after 3 years. Baseline characteristics were potential predictors of MP decline. RESULTS: Of the 1,052 subjects performing normally at baseline, 166 (15.8%) had declined in MP at follow-up. Older age, female sex, lower education, symptoms of distal symmetrical neuropathy, cognitive impairment without dementia, parkinsonism, heart failure, anemia, depressive symptoms, worse Mini-Mental State Examination score, and lost activities of daily living and instrumental activities of daily living (IADLs) were significantly associated with MP decline in univariate comparisons. Older age (odds ratio (OR) = 3.84, 95% confidence interval (CI) = 2.14-6.88 comparing age classes > or =80 with 65-69), female sex (OR=1.50, 95% CI = 1.03-2.20), distal symmetric neuropathy (OR = 2.00, 95% CI = 1.03-3.87), depressive symptoms (OR = 1.85, 95% CI = 1.17-2.24), and baseline IADLs (OR = 1.22, 95% CI = 1.08-1.37 for each lost activity) independently predicted MP decline after regression analysis. CONCLUSION: In a population-based cohort of elderly people with normal MP, one-sixth declined in 3 years. Age, sex, distal symmetrical neuropathy, depressive symptoms, and baseline IADLs independently predicted this decline. Distal symmetrical neuropathy is underestimated in the clinical and epidemiological evaluation of motor decline in older people.
机译：目的：以最初观察时表现正常的受试者为对象，研究运动表现（MP）下降的风险和预测因素。设计：队列研究。地点：意大利纵向老龄化研究的子样本（65-84岁）。参与者：152名基线时MP正常的受试者（平均年龄+/-标准差= 71 +/- 5，男性占69％）。测量：使用六项测试（从椅子上站起来，加紧，双人步行，单腿站立，步行速度和180度旋转步幅）评估基线和3年后的MP。基线特征是MP下降的潜在预测指标。结果：在1,052名基线时表现正常的受试者中，有166名（15.8％）在随访时MP下降。老年人，女性，受教育程度较低，远端对称性神经病的症状，无痴呆的认知障碍，帕金森病，心力衰竭，贫血，抑郁症状，小精神状态检查成绩较差，日常生活活动和日常器械活动丧失（IADLs）与单因素比较中MP下降显着相关。年龄较大（比值比（OR）= 3.84，95％置信区间（CI）= 2.14-6.88，比较年龄类别>或= 80和65-69），女性（OR = 1.50，95％CI = 1.03-2.20） ，远端对称性神经病（OR = 2.00，95％CI = 1.03-3.87），抑郁症状（OR = 1.85，95％CI = 1.17-2.24）和基线IADL（OR = 1.22，95％CI = 1.08-1.37每个损失的活动）在回归分析后独立预测MP下降。结论：在以MP为基础的老年人群中，三年内有六分之一的人下降。年龄，性别，远端对称性神经病，抑郁症状和基线IADLs独立预测了这一下降。在老年人运动功能下降的临床和流行病学评估中，远侧对称性神经病被低估了。

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