Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety

Figueiredo IM; dos Santos LV; da Costa WF; de Carvalho JE; da Silva CC; Sacoman JL; Kohn LK; Sarragiotto MH

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Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety

机译：具有取代的硫脲部分的新型柠檬烯衍生物的合成及其抗增殖活性

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A series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative activity against human cancer cell lines. Compounds bearing aromatic substituents (3-6) exhibit cytotastic activity in the full panel of cell lines tested, with GI(50) values in the range of 2.5 to 24 mu mol L-1. Compounds 3, 10, 12 and 16 were the most active with GI(50) values in the range of 0.41 to 3.0 mu mol L-1, against different cell lines.

机译：合成了一系列带有取代的硫脲部分的R-（+）-柠檬烯衍生物（3-13）和五个S-甲基类似物（14-18），并评估了它们对人癌细胞的体外抗增殖活性。带有芳族取代基（3-6）的化合物在整个测试的细胞系中均表现出细胞分裂活性，GI（50）值在2.5至24μmolL-1范围内。化合物3、10、12和16对不同细胞系的GI（50）值在0.41至3.0μmolL-1范围内最具活性。

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来源
《Journal of the Brazilian Chemical Society》 |2006年第5期|共7页
作者
Figueiredo IM; dos Santos LV; da Costa WF; de Carvalho JE; da Silva CC; Sacoman JL; Kohn LK; Sarragiotto MH;
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正文语种 eng
中图分类化学;
关键词
limonene derivatives; thioureas; antiproliferative activity; CANCER; INHIBITION; OILS;

机译：柠檬烯衍生物;硫脲;抗增殖活性;癌症;抑制作用;油类;

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1. Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety [J] . Cleuza C. Da Silva, Isis M. Figueiredo, Jo?o E. De Carvalho, Journal of the Brazilian Chemical Society . 2006,第5期

机译：具有取代的硫脲部分的新型柠檬烯衍生物的合成及其抗增殖活性
2. Synthesis and Biological Activity of Substituted Urea and Thiourea Derivatives Containing 1,2,4-Triazole Moieties [J] . Bedia Kocyigit-Kaymakcioglu, Ahmet Ozgur Celen, Nurhayat Tabanca Molecules . 2013,第3期

机译：含1,2,4-三唑部分的尿素和硫脲衍生物的合成及生物活性
3. Synthesis and Biological Activity of Substituted Urea and Thiourea Derivatives Containing 1,2,4-Triazole Moieties [J] . Abbas Ali, Ahmet Ozgur Celen, Bedia Kocyigit-Kaymakcioglu, Molecules . 2013,第3期

机译：含1,2,4-三唑部分的尿素和硫脲衍生物的合成及生物活性
4. Synthesis and Antiproliferative activities of Novel 2-Phenylaminopyrimidine (PAP) Derivatives [C] . Sheng Chang International Conference on Materials and Products Manufacturing Technology . 2014

机译：新型2-苯基氨基嘧啶（PAP）衍生物的合成与抗增殖活性
5. THE SYNTHESIS AND CHEMICAL REACTIVITY OF THE S-OXIDES OF THIOUREA AND ITS MONO- AND 1,3-DISUBSTITUTED DERIVATIVES (UREA) [D] . BISCHOFF, JUDITH J. 1987

机译：硫脲及其单-和1,3-二取代衍生物（脲）的S-氧化物的合成和化学反应性
6. Synthesis and Biological Activity of Substituted Urea and Thiourea Derivatives Containing 124-Triazole Moieties [O] . Bedia Kocyigit-Kaymakcioglu, Ahmet Ozgur Celen, Nurhayat Tabanca, 2013

机译：含124-三唑部分的尿素和硫脲衍生物的合成及其生物活性
7. Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety [O] . Figueiredo, Isis M., Santos, Luciane V. dos, Costa, Willian F. da, 2015

机译：具有取代的硫脲部分的新型柠檬烯衍生物的合成及其抗增殖活性
8. Synthesis and Biological Activity of Substituted Urea and Thiourea Derivatives Containing 1,2,4-Triazole Moieties. [R] . Kocyigit-Kaymakcioglu, B., Celen, A. O., Tabanca, N., 2013

机译：含1,2,4-三唑部分的取代脲和硫脲衍生物的合成及生物活性。

Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety

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