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首页> 外文期刊>Clinical nephrology >A case of acute phosphate nephropathy in a patient with nephrotic syndrome and decreased serum fetuin-A.
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A case of acute phosphate nephropathy in a patient with nephrotic syndrome and decreased serum fetuin-A.

机译:肾病综合征并血清胎球蛋白-A减少的患者中的一例急性磷酸盐肾病。

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摘要

We report a case of APN after OSP use in a patient with nephrotic syndrome (NS). Renal biopsy revealed minimal change disease with multifocal calcium phosphate deposits within the tubules and in the interstitium. The serum level of fetuin-A, a systemic calcification inhibitor, was low during severely proteinuric state but normalized after remission of NS. To verify whether fetuin-A levels are low in NS patients, serum fetuin-A levels were determined in 10 patients with NS and 10 with asymptomatic microscopic hematuria (H). The mean serum fetuin-A levels were significantly lower in the NS group compared to the H group (p < 0.01). This finding suggests that a lower serum fetuin-A level may be associated with APN after OSP use in patients with NS, thus careful attention should be paid when colonoscopy using OSP is scheduled in this population.
机译:我们报告OSP患者肾病综合征(NS)后使用APN的情况。肾活检显示微管病变,肾小管和间质内多灶性磷酸钙沉积。胎蛋白A(一种全身性钙化抑制剂)的血清水平在严重蛋白尿状态时较低,但在NS缓解后恢复正常。为了验证NS患者的胎球蛋白A水平是否较低,在10例NS患者和10例无症状性血尿(H)患者中测定了血清Fetuin A水平。与H组相比,NS组的平均血清胎球蛋白A水平显着降低(p <0.01)。这一发现表明,NS患者OSP使用后,血清胎球蛋白-A水平可能与APN相关,因此,在该人群中计划使用OSP进行结肠镜检查时应格外注意。

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