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首页> 外文期刊>Clinical neuropathology >Granular cell tumor of intracranial meninges.
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Granular cell tumor of intracranial meninges.

机译：颅内脑膜的颗粒细胞瘤。

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BACKGROUND: Granular cell tumor (GCT) is a benign neoplasm composed of a proliferation of round or polygonal cells that contain eosinophilic granular cytoplasm. The most common locations are tongue and subcutaneous tissue, but a variety of other sites may be involved including the central nervous system (CNS). Most CNS GCT arise in the pituitary, but rare cases involving brain and leptomeninges have been described. Extracranial GCT are usually S-100-positive, but those of the CNS, as well as the congenital variant of GCT, can be S-100-negative. CASE REPORT: We report an incidental autopsy finding of a 2.5 mm GCT that arose in the intracranial meninges overlying the anterior superior cerebellar vermis. RESULTS: The neoplasm had abundant eosinophilic, granular cytoplasm that was PAS-positive and diastase-resistant. Immunohistochemical studies showed that the neoplasm was positive for CD68 and negative for S-100, GFAP, EMA, and keratin. Thus, the immunophenotype is consistent with non-neural origin. CONCLUSION: Although this lesion in this circumstance was of no clinical significance, knowledge of the occurrence of GCT at this site broadens the differential diagnosis of eosinophilic lesions of the leptomeninges.
机译：背景：颗粒细胞瘤（GCT）是一种良性肿瘤，由圆形或多边形细胞的增殖组成，其中包含嗜酸性粒细胞质。最常见的位置是舌头和皮下组织，但是可能会涉及多种其他位置，包括中枢神经系统（CNS）。大多数中枢神经系统GCT发生在垂体中，但是已经描述了涉及脑和软脑膜炎的罕见病例。颅外GCT通常为S-100阳性，但中枢神经系统以及GCT的先天性变异可能为S-100阴性。病例报告：我们报告了在2.5毫米GCT的偶然尸检结果，该GCT发生在小脑前上mis骨上方的颅内脑膜中。结果：该肿瘤具有丰富的嗜酸性粒状细胞质，呈PAS阳性且对淀粉酶具有抵抗力。免疫组织化学研究表明，肿瘤的CD68阳性，而S-100，GFAP，EMA和角蛋白阴性。因此，免疫表型与非神经起源是一致的。结论：尽管在这种情况下该病变无临床意义，但了解该部位GCT的发生可扩大对软脑膜嗜酸性病变的鉴别诊断。

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