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首页> 外文期刊>Journal of the European Academy of Dermatology and Venereology: JEADV >Incidence of tuberculosis infection in psoriatic patients on anti-TNF therapy: report of a case series with 144 patients.
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Incidence of tuberculosis infection in psoriatic patients on anti-TNF therapy: report of a case series with 144 patients.

机译：接受抗TNF治疗的银屑病患者的肺结核感染发生率：144例患者的病例系列报告。

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BACKGROUND: Worldwide clinical trials and post-marketing surveillance data have demonstrated an increased incidence of tuberculosis (TB) disease associated with antitumour necrosis factor (anti-TNF) agents. The majority of these cases are presumed to result from a reactivation of latent disease, while the rate of new infections is unknown. A study was performed to evaluate th incidence of latent tuberculosis infection (LTBI) in psoriatic patients screened for biological therapy in a high-incidence area, such as Madrid, Spain. PATIENTS AND METHODS: One hundred and forty-four patients with moderate-to-severe psoriasis treated with anti-TNF agents were recruited. All of them were screened for active TB or LTBI before therapy. The screening included a detailed medical study, physical examination, chest X-ray, tuberculin skin test (TST) with purified protein derivative and re-TST. RESULTS: A total of 42 (29%) patients were diagnosed with LTBI based on a positive TST or re-TST, and/or signs of past TB in the chest X-ray. All of them received chemoprophylaxis with isoniazide. One patient developed a primary active lymphnode TB. CONCLUSION: This is the first study to underscore the incidence of LTBI in patients with psoriasis treated with anti-TNF therapy in the Spanish population. We support that the use of TST is still reliable and an effective diagnostic method for the detection of LTBI in anti-TNF therapy.
机译：背景：全球临床试验和上市后的监测数据表明，与抗肿瘤坏死因子（anti-TNF）药物相关的结核病（TB）发病率增加。这些病例中的大多数被认为是由于潜伏疾病的重新激活而引起的，而新感染的发生率尚不清楚。进行了一项研究，以评估在高发病率地区（例如西班牙马德里）进行了生物疗法筛查的银屑病患者中潜伏性结核感染（LTBI）的发生率。病人和方法：招募了144例接受抗TNF药物治疗的中重度牛皮癣患者。在治疗前对所有患者进行了活动性结核病或LTBI筛查。筛查包括详细的医学研究，体格检查，胸部X线检查，含纯化蛋白衍生物和re-TST的结核菌素皮肤试验（TST）。结果：根据TST或re-TST阳性和/或胸部X线检查是否有结核病的诊断，共有42例（29％）患者被诊断为LTBI。他们都接受了异烟肼的化学预防。一名患者发展为原发性活动淋巴结结核。结论：这是第一项强调西班牙人群抗TNF治疗牛皮癣患者LTBI发生率的研究。我们支持使用TST仍然是可靠的方法，并且是抗TNF治疗中检测LTBI的有效诊断方法。

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