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首页> 外文期刊>Journal of the European Academy of Dermatology and Venereology: JEADV >Oral lichen planus: an unusual cause of facial and abducens nerve paralysis associated with conjunctival and oesophageal involvement.
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Oral lichen planus: an unusual cause of facial and abducens nerve paralysis associated with conjunctival and oesophageal involvement.

机译：口腔扁平苔藓：与结膜和食道受累相关的面部和外展神经麻痹的异常原因。

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摘要

ABSTRACT Lichen planus (LP) is a T-cell-mediated disorder that may involve the skin, nails and mucosal surfaces. Conjunctival, laryngeal and oesophageal involvement were reported to be extremely rare manifestations of the disease. In this report, we present an oral LP case who complained of severe burning pain on his tongue and oral mucosa caused by ulcerative lesions and associated with conjunctival, laryngeal and oesophageal involvement. In addition, neurological examination revealed facial and abducens nerve palsy. To the best of our knowledge, we are presenting the first case of erosive oral LP associated with facial and abducens nerve paralysis. Although this association may be coincidental, according to an immunological concept proposed to explain the pathogenesis of Bell's palsy, degranulation of mast cells activated by complement or specific allergens with the release of histamine and other substances were to be presented responsible from nerve oedema, ischaemia and paralysis. As mast cell mediators are likely to be involved in the immunopathogenesis of OLP, we think that the cause of facial and bilateral abducens nerve palsy could be explained by the same mechanism. This case is a good example of the need for team work in lichen planus patients undergoing interdisciplinary consultations.
机译：摘要扁平苔藓（LP）是T细胞介导的疾病，可能涉及皮肤，指甲和粘膜表面。据报道，结膜，喉和食道受累是该病极为罕见的表现。在本报告中，我们介绍了一个口服LP病例，该病例抱怨溃疡性病变引起的舌头和口腔粘膜严重灼痛，并伴有结膜，喉和食道受累。此外，神经系统检查发现面部和外展神经麻痹。据我们所知，我们正在介绍第一例与面部和外展神经麻痹相关的口腔侵蚀性LP。尽管这种关联可能是偶然的，但根据提议用来解释贝尔麻痹发病机理的免疫学概念，应提出由补体或特定变应原激活的肥大细胞脱粒并释放组胺和其他物质，原因是神经水肿，局部缺血和麻痹。由于肥大细胞介体可能参与OLP的免疫发病机制，因此我们认为面部和双侧外展神经麻痹的原因可以用相同的机制解释。这个案例很好地说明了进行跨学科咨询的扁平苔藓患者需要团队合作的情况。

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