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首页> 外文期刊>Journal of the International Neuropsychological Society: JINS >Long-term neural processing of attention following early childhood traumatic brain injury: fMRI and neurobehavioral outcomes.
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Long-term neural processing of attention following early childhood traumatic brain injury: fMRI and neurobehavioral outcomes.

机译：儿童早期脑外伤后长期注意的神经处理：功能磁共振成像和神经行为预后。

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摘要

Attentional deficits are common and significant sequelae of pediatric traumatic brain injury (TBI). However, little is known about how the underlying neural processes that support different components of attention are affected. The present study examined brain activation patterns using fMRI in a group of young children who sustained a TBI in early childhood (n = 5; mean age = 9.4), and a group of age-matched control children with orthopedic injuries (OI) (n = 8) during a continuous performance task (CPT). Four children in the TBI group had moderate injuries, and one had a severe injury. Performance on the CPT task did not differ between groups. Both TBI and OI children activated similar networks of brain regions relevant to sustained attention processing, but the TBI group demonstrated several areas of significantly greater activation relative to controls, including frontal and parietal regions. These findings of over-activation of the relevant attention network in the TBI group contrast with those obtained in imaging studies of Attention-Deficit/Hyperactivity Disorder where under-activation of the attention network has been documented. This study provides evidence that young children's brains function differently following a traumatic brain injury, and that these differences persist for years after the injury.
机译：注意缺陷是小儿外伤性脑损伤（TBI）的常见且显着的后遗症。但是，对于支持不同注意组件的潜在神经过程如何受到影响知之甚少。本研究使用fMRI检查了一组在早期儿童中患有TBI的幼儿（n = 5;平均年龄= 9.4）和一组年龄匹配的骨科损伤（OI）对照儿童的大脑激活模式（n = 8）在持续执行任务（CPT）期间。 TBI组中有4名儿童受到中度伤害，其中1名受到了严重伤害。各小组在CPT任务上的表现没有差异。 TBI和OI儿童均激活了与持续注意力加工相关的相似的大脑区域网络，但是TBI组显示了相对于对照而言明显增强的几个区域，包括额叶和顶叶区域。 TBI组中相关注意网络过度激活的这些发现与注意力不足/多动障碍影像学研究中发现的结果相反，在该研究中已记录了注意网络激活不足。这项研究提供了证据，表明幼儿脑部受伤后大脑的功能有所不同，并且这些差异在受伤后的数年中持续存在。

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