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首页> 外文期刊>Journal of the International Neuropsychological Society: JINS >Fusing Functional MRI and Diffusion Tensor Imaging Measures of Brain Function and Structure to Predict Working Memory and Processing Speed Performance among Inter-episode Bipolar Patients
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Fusing Functional MRI and Diffusion Tensor Imaging Measures of Brain Function and Structure to Predict Working Memory and Processing Speed Performance among Inter-episode Bipolar Patients

机译：融合功能性MRI和脑部功能和结构的弥散张量成像测量方法来预测两相间双相型患者的工作记忆和处理速度表现

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摘要

Evidence for abnormal brain function as measured with diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) and cognitive dysfunction have been observed in inter-episode bipolar disorder (BD) patients. We aimed to create a joint statistical model of white matter integrity and functional response measures in explaining differences in working memory and processing speed among BD patients. Medicated inter-episode BD (n=26; age=45.2 +/- 10.1 years) and healthy comparison (HC; n=36; age=46.3 +/- 11.5 years) participants completed 51-direction DTI and fMRI while performing a working memory task. Participants also completed a processing speed test. Tract-based spatial statistics identified common white matter tracts where fractional anisotropy was calculated from atlas-defined regions of interest. Brain responses within regions of interest activation clusters were also calculated. Least angle regression was used to fuse fMRI and DTI data to select the best joint neuroimaging predictors of cognitive performance for each group. While there was overlap between groups in which regions were most related to cognitive performance, some relationships differed between groups. For working memory accuracy, BD-specific predictors included bilateral dorsolateral prefrontal cortex from fMRI, splenium of the corpus callosum, left uncinate fasciculus, and bilateral superior longitudinal fasciculi from DTI. For processing speed, the genu and splenium of the corpus callosum and right superior longitudinal fasciculus from DTI were significant predictors of cognitive performance selectively for BD patients. BD patients demonstrated unique brain-cognition relationships compared to HC. These findings are a first step in discovering how interactions of structural and functional brain abnormalities contribute to cognitive impairments in BD.
机译：在弥散性双相情感障碍（BD）患者中，已观察到弥散张量成像（DTI）和功能磁共振成像（fMRI）测得的脑功能异常的证据，以及认知功能障碍。我们旨在建立白质完整性和功能反应措施的联合统计模型，以解释BD患者之间的工作记忆和处理速度差异。药物治疗的情节性BD（n = 26;年龄= 45.2 +/- 10.1岁）和健康对照（HC; n = 36;年龄= 46.3 +/- 11.5岁）参与者在执行工作时完成了51方向DTI和fMRI记忆任务。参与者还完成了处理速度测试。基于路线的空间统计信息确定了常见的白质区域，其中根据地图集定义的感兴趣区域计算了分数各向异性。还计算了感兴趣区域激活簇内的大脑反应。最小角度回归用于融合fMRI和DTI数据，以选择各组认知表现的最佳关节神经影像预测指标。尽管在区域之间与认知表现最相关的小组之间存在重叠，但小组之间的某些关系有所不同。对于工作记忆的准确性，BD特定的预测因子包括来自fMRI的双侧背外侧前额叶皮层，call体脾，左束状筋膜和来自DTI的双侧上纵筋膜。对于处理速度，call体的属和脾以及DTI的右上纵筋膜是BD患者选择性认知功能的重要预测指标。与HC相比，BD患者表现出独特的大脑认知关系。这些发现是发现结构性和功能性脑部异常相互作用如何导致BD认知障碍的第一步。

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