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首页> 外文期刊>Journal of the International Neuropsychological Society: JINS >Upper and Lower Extremity Motor Function and Cognitive Impairment in Multiple Sclerosis
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Upper and Lower Extremity Motor Function and Cognitive Impairment in Multiple Sclerosis

机译：多发性硬化症的上，下肢运动功能和认知障碍

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摘要

Motor impairments and cognitive dysfunction are common in multiple sclerosis (MS). We aimed to delineate the relationship between cognitive capacity and upper and lower motor function in 211 MS patients, and 120 healthy volunteers. Lower and upper motor function were assessed with the Timed 25 Foot Walk (T25FW) and the Nine Hole Peg Test (NHPT) as implemented in the Multiple Sclerosis Functional Composite (MSFC). Subjects also underwent neuropsychological evaluation. Hierarchical linear regression analysis was conducted separately for the MS and healthy groups with the T25FW and NHPT serving as the outcome measures. Cognitive performance indices served as predictors. As expected, healthy subjects performed better than the MS group on all measures. Processing speed and executive function tests were significant predictors of lower and upper motor function in both groups. Correlations were more robust in the MS group, where cognitive tests predicted variability in motor function after controlling for disease duration and physical disability. In conclusion, we find evidence of higher order cognitive control of motor function that appears to be particularly salient in this large and representative MS sample. The findings may have implications for risk assessment and treatment of mobility dysfunction in MS.
机译：运动障碍和认知功能障碍在多发性硬化症（MS）中很常见。我们旨在描述211名MS患者和120名健康志愿者的认知能力与上下运动功能之间的关系。通过定时25步步行（T25FW）和多发性硬化功能复合材料（MSFC）中实施的九孔钉测试（NHPT）评估上下运动功能。受试者还接受了神经心理学评估。对MS组和健康组分别进行了分层线性回归分析，其中T25FW和NHPT作为结果指标。认知表现指标可作为预测指标。正如预期的那样，在所有方面，健康受试者的表现均优于MS组。加工速度和执行功能测试是两组下，上运动功能的重要预测指标。 MS组的相关性更强，其中认知测试预测了控制疾病持续时间和身体残疾后运动功能的可变性。总而言之，我们发现运动功能的高阶认知控制的证据在这一庞大而有代表性的MS样本中显得尤为突出。这些发现可能对MS的风险评估和行动不便的治疗有影响。

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