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首页> 外文期刊>Journal of the International Neuropsychological Society: JINS >Deteriorated executive functions in patients with successful surgery for pituitary adenomas compared with other chronically ill patients.
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Deteriorated executive functions in patients with successful surgery for pituitary adenomas compared with other chronically ill patients.

机译：与其他慢性病患者相比，成功进行垂体腺瘤手术的患者的执行功能恶化。

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摘要

Pituitary adenomas, even after successful treatment, are associated with cognitive impairments. It is unclear whether these deficits are a consequence of unspecific factors associated with having a chronic illness and whether the cognitive dysfunctions exceed those of other chronically ill patients. Thirty-eight patients with transsphenoidal surgery for pituitary adenomas and 38 patients undergoing L-thyroxine replacement therapy after thyroid surgery were studied neuropsychologically with established tests. Executive function was examined with the Trail-Making Test A and B, working memory with the digit span test, attention with the digit symbol test, verbal memory with the German version of the Auditory Verbal Learning and Memory Test, and general verbal intelligence by a vocabulary test. Attention (p = .007), attentional speed (p = .0004), executive control (p = .04), and working memory (p = .01), were significantly reduced in patients with pituitary adenomas compared with other chronically ill patients. In contrast, no differences were found between the groups for verbal memory (all subtests: p >/= .06). Patients with successful surgery for pituitary adenomas show also in comparison with other chronically ill patients an increased risk for deficits in certain aspects of cognitive function, including attention and working memory, supporting the relevance of the brain lesion and its treatment for these dysfunctions.
机译：垂体腺瘤即使治疗成功也与认知障碍有关。目前尚不清楚这些缺陷是否是与患有慢性疾病相关的非特异性因素的结果，以及认知功能障碍是否超过其他慢性病患者的认知障碍。对38例经蝶窦手术治疗的垂体腺瘤患者和38例在甲状腺手术后接受L-甲状腺素替代疗法的患者进行了既定测试的神经心理学研究。执行功能通过试行测试A和B进行测试，工作记忆通过数字跨度测试进行测试，注意力通过数字符号测试进行测试，言语记忆通过听觉语言学习和记忆测试的德语版进行，普通言语智能通过a词汇测试。与其他慢性病患者相比，垂体腺瘤患者的注意力（p = .007），注意力速度（p = .0004），执行控制（p = .04）和工作记忆（p = .01）显着降低。 。相反，在语言记忆的各组之间没有发现差异（所有子测试：p> / = .06）。与其他慢性病患者相比，成功进行垂体腺瘤手术的患者还显示出认知功能某些方面（包括注意力和工作记忆）缺陷的风险增加，这支持了脑部病变及其对这些功能障碍的治疗。

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