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首页> 外文期刊>Journal of the experimental analysis of behavior >Pramipexole-induced disruption of behavioral processes fundamental to intertemporal choice
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Pramipexole-induced disruption of behavioral processes fundamental to intertemporal choice

机译：普拉克索诱导的对跨期选择至关重要的行为过程的破坏

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Evaluating the effects of presession drug administration on intertemporal choice in nonhumans is a useful approach for identifying compounds that promote impulsive behavior in clinical populations, such as those prescribed the dopamine agonist pramipexole (PPX). Based on the results of previous studies, it is unclear whether PPX increases rats' impulsive choice or attenuates aspects of stimulus control. The present study was designed to experimentally isolate behavioral processes fundamental to intertemporal choice and challenge them pharmacologically with PPX administration. In Experiment 1, the hypothesis that PPX increases impulsive choice as a result of enhanced sensitivity to reinforcer delays was tested and disconfirmed. That is, acute PPX diminished delay sensitivity in a manner consistent with disruption of stimulus control whereas repeated PPX had no effect on delay sensitivity. Experiments 2 and 3 elaborated upon this finding by examining the effects of repeated PPX on rats' discrimination of response-reinforcer contingencies and reinforcer amounts, respectively. Accuracy of both discriminations was reduced by PPX. Collectively these results provide no support for past studies that have suggested PPX increases impulsive choice. Instead, PPX impairs stimulus control over choice behavior. The behavioral approach adopted herein could be profitably integrated with genetic and other biobehavioral models to advance our understanding of impulsive behavior associated with drug administration.
机译：评估会前给药对非人的跨时选择的影响是一种有用的方法，可用于识别在临床人群中促进冲动行为的化合物，例如开处方的多巴胺激动剂普拉克索（PPX）。根据先前的研究结果，尚不清楚PPX是否会增加大鼠的冲动选择或减弱刺激控制的方面。本研究旨在通过实验分离对跨期选择至关重要的行为过程，并通过PPX给药在药理上挑战它们。在实验1中，关于PPX由于增强器延迟的敏感性增强而增加了冲动选择的假设得到了检验和证实。即，急性PPX以与刺激控制的破坏一致的方式降低了延迟敏感性，而重复的PPX对延迟敏感性没有影响。实验2和3通过检查重复PPX分别对大鼠辨别应答增强剂的情况和增强剂的量的影响，详细阐述了这一发现。 PPX降低了两种区分的准确性。这些结果共同为过去的研究提供了支持，这些研究表明PPX增加了冲动选择。相反，PPX削弱了对选择行为的刺激控制。本文采用的行为方法可以与遗传和其他生物行为模型进行有益的整合，以增进我们对与药物管理相关的冲动行为的理解。

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