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首页> 外文期刊>Journal of the Korean Fisheries Society >Studies on physicochemical and biological properties of depolymerized alginate from sea tangle, Laminaria japonicus by thermal decomposition: 2. changes in antimutagenicity effects and cholesterol, glucose and cadmium (Cd) binding capacity of depolym
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Studies on physicochemical and biological properties of depolymerized alginate from sea tangle, Laminaria japonicus by thermal decomposition: 2. changes in antimutagenicity effects and cholesterol, glucose and cadmium (Cd) binding capacity of depolym

机译：通过热分解研究海藻，海带中解聚的藻酸盐的理化和生物学特性：2.抗聚变作用以及胆固醇，葡萄糖和镉（Cd）结合能力的变化

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摘要

To improve functionality and characteristics of alginate from the sea tangle, Laminaria japonicus, partially depolymerized alginates (HAG-10, average molecular weight 10,000; HAG-SO, average molecular weight 50,000; HAG-100, average molecular weight 100,000) were obtained with hydrolysis of alginate by heating at 121 deg C. Effects of the depolymerization on physicochemical properties were investigated in the antimutagenicity and binding capacity of cholesterol, glucose and cadmium. In the Ames mutagenicity test using Salmonella typhimudum TA 100, HAG-10, HAG-50, HAG-100 and intact alginate reduced effectively the mutagenicities induced by aflatoxin B_1 (AFB_1) and N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) and HAG-10 showed the strongest antimutagenicity among the tested samples. The binding capacity of cholesterol, glucose and cadmium at different pH in vitro depended highly on molecular weight of alginate, and the changes in binding capacity at different pH was not different.
机译：为了改善海藻中海藻酸盐的功能和特性，通过水解获得了海带部分解聚的海藻酸盐（HAG-10，平均分子量10,000; HAG-SO，平均分子量50,000; HAG-100，平均分子量100,000）。通过在121℃下加热来制备藻酸盐。在胆固醇，葡萄糖和镉的抗诱变性和结合能力方面研究了解聚对理化性质的影响。在使用鼠伤寒沙门氏菌TA 100进行的Ames致突变性测试中，HAG-10，HAG-50，HAG-100和完整藻酸盐可有效降低黄曲霉毒素B_1（AFB_1）和N-甲基-N'-硝基-N-亚硝基胍诱导的致突变性（ MNNG）和HAG-10在测试样品中显示出最强的抗突变性。体外不同pH条件下胆固醇，葡萄糖和镉的结合能力高度依赖于藻酸盐的分子量，不同pH条件下结合能力的变化无差异。

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