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首页> 外文期刊>Clinical neurophysiology >Somatosensory evoked potentials in attention deficit/hyperactivity disorder and tic disorder.
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Somatosensory evoked potentials in attention deficit/hyperactivity disorder and tic disorder.

机译：注意缺陷/多动障碍和抽动障碍的体感诱发电位。

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摘要

OBJECTIVE: Both attention deficit/hyperactivity disorder (ADHD) and chronic tic disorder (TD) are hyperkinetic disorders. These disorders often coexist with each other and frequently have sensory components. Therefore, we hypothesized that they might have a common pathophysiology involving the somatosensory system, especially hyper-excitabilities of primary somatosensory area. METHODS: To evaluate sensory system excitability, we examined somatosensory evoked potentials (SEP) elicited by median nerve stimulation in 18 children with ADHD and 18 children with TD. RESULTS: Three children with ADHD and 8 children with TD showed giant SEP and the peak-to-peak amplitude for N20-P25 was also significantly greater than that obtained from normally developing children (P<0.05 for ADHD and P<0.01 for TD). Children with TD had significant left-ward asymmetry of N20-P25 (P<0.01) and higher left-hemispheric N20-P25 than children with ADHD (P<0.05). CONCLUSIONS: Although hyper-excitability of the primary somatosensoryarea is a common characteristic for ADHD and TD, its severity, especially in the left-hemisphere, differs (i.e. TD has left-ward hyper-excitability). SIGNIFICANCE: The possibility remains that hyper-excitability of the primary somatosensory area is a reason why these disorders often coexist with each other and left-ward hyper-excitability of the primary somatosensory area is a unique feature of TD described for the first time.
机译：目的：注意力缺陷/多动障碍（ADHD）和慢性抽动症（TD）都是运动过度障碍。这些疾病通常彼此并存，并经常具有感觉成分。因此，我们假设它们可能具有涉及体感系统的共同病理生理学，尤其是主要体感区的过度兴奋性。方法：为了评估感觉系统的兴奋性，我们研究了中位神经刺激对18例ADHD和18 TD患儿的体感诱发电位（SEP）。结果：3例多动症儿童和8例TD儿童表现出巨大的SEP，N20-P25的峰峰幅度也显着大于正常发育儿童（ADHD的P <0.05，TD的P <0.01） 。 TD患儿比ADHD患儿的N20-P25明显偏左（P <0.01），左半球N20-P25偏高（P <0.05）。结论：尽管原发性躯体感觉过敏症的过度兴奋性是ADHD和TD的共同特征，但其严重性（尤其是在左半球）有所不同（即TD具有向左的过度兴奋性）。意义：主要体感区的过度兴奋性是这些疾病经常彼此并存的原因，而主要体感区的向左向过度兴奋性是首次描述的TD的特征。

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