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首页> 外文期刊>Clinical neurophysiology >Electrical low-frequency stimulation induces homotopic long-term depression of nociception and pain from hand in man.
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Electrical low-frequency stimulation induces homotopic long-term depression of nociception and pain from hand in man.

机译：低频电刺激会导致同种异型的长期伤害感和手感疼痛。

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OBJECTIVE: Electrical low-frequency stimulation (LFS) of cutaneous afferents evokes long-term depression (LTD) of nociception. In vitro studies suggest a sole homosynaptic effect on the conditioned pathway. The present study addresses homotopy of LTD in human nociception and pain. METHODS: In 30 healthy volunteers, nociceptive Adelta fibers were electrically stimulated by a concentric electrode. Test stimulation (0.125Hz) was alternately applied unilateral to radial and ulnar side of right hand dorsum (ExpUni) or bilateral to radial side of right and left hand dorsum (ExpBi). Conditioning LFS (1Hz, 1200 pulses) was applied to radial side of right hand dorsum. Somatosensory evoked cortical vertex potentials (SEP) were recorded, and volunteers rated stimulus intensity. RESULTS: After homotopic LFS, SEP amplitude (ExpUni: -34.6%; ExpBi: -33.6%) and pain rating (ExpUni: -44.1%; ExpBi: -29.1%) significantly decreased. Amplitude reduction after heterotopic LFS did not differ from habituation effects in Control experiment without LFS. Heterotopic pain perception was not affected. CONCLUSIONS: The electrophysiological and psychophysical study on synaptic plasticity in healthy man demonstrates homotopic organization of LTD. SIGNIFICANCE: Homotopy is probably due to a homosynaptic effect at first nociceptive synapse, but descending inhibitory systems may also be involved. These experiments may help to judge the potency of LTD for future therapy in chronic pain.
机译：目的：皮肤传入神经的低频刺激（LFS）引起长期的伤害感受（LTD）。体外研究表明，对条件途径具有唯一的同源突触作用。本研究解决了LTD在人类伤害感受和疼痛中的同态性。方法：在30名健康志愿者中，通过同心电极电刺激伤害性Adelta纤维。将测试刺激（0.125Hz）交替施加到右手背的radial骨和尺侧（ExpUni）或双边施加到右手背和left骨的radial侧（ExpBi）。将条件LFS（1Hz，1200个脉冲）应用于右手背的radial侧。记录体感诱发皮层顶点电位（SEP），志愿者对刺激强度进行评估。结果：经过同位LFS后，SEP振幅（ExpUni：-34.6％; ExpBi：-33.6％）和疼痛等级（ExpUni：-44.1％; ExpBi：-29.1％）明显降低。在没有LFS的对照实验中，异位LFS后的振幅降低与习惯效应没有差异。异位疼痛知觉不受影响。结论：健康人的突触可塑性的电生理和心理生理研究证明了LTD的同位组织。重要性：同型可能是由于在最初的伤害性突触中具有同突触作用，但也可能涉及下降的抑制系统。这些实验可能有助于判断LTD在未来治疗慢性疼痛中的效力。

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