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首页> 外文期刊>Journal of the Korean Society for Applied Biological Chemistry >Two Base Mutations of a Putative LacI-family Transcriptional Regulator, SCO7554, Reverse the Overexpression Effect on the Antibiotic Pigment Production in Streptomyces coelicolor
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Two Base Mutations of a Putative LacI-family Transcriptional Regulator, SCO7554, Reverse the Overexpression Effect on the Antibiotic Pigment Production in Streptomyces coelicolor

机译：推定的LacI家族转录调节剂SCO7554的两个碱基突变，逆转天蓝色链霉菌抗生素色素生产的过表达效应。

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摘要

The SCO7554 protein, a putative Lad-family transcriptional regulator, is important in the antibiotic pigment production in Streptomyces coelicolor M130. A single mutation at the 4th amino acid from asparagine to serine reversed the SCO7554 effect on the antibiotic pigment production in an overexpression experiment. Additional mutation at the 276th amino acid from valine to alanine intensified this effect, and the overexpression of the double mutant SCO7554 increased the production of antibiotics, whereas the overexpression of SCO7554 itself decreased the antibiotic productions. This observation suggested the functional importance of the N-terminal region of a putative Lad-family transcriptional regulator, SCO7554 protein, even though it was not located on any known functional domain.
机译：SCO7554蛋白是推定的Lad家族转录调节因子，在Coelicolor M130链霉菌的抗生素色素生产中很重要。在过表达实验中，从天冬酰胺到丝氨酸的第4个氨基酸的单个突变逆转了SCO7554对抗生素色素生成的影响。从缬氨酸到丙氨酸在第276个氨基酸处的额外突变增强了这种作用，双重突变SCO7554的过表达增加了抗生素的产生，而SCO7554本身的过表达则降低了抗生素的产生。该观察结果表明推定的Lad家族转录调节因子SCO7554蛋白N端区域的功能重要性，即使它不在任何已知的功能域上也是如此。

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