• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the Korean Society for Applied Biological Chemistry >Evaluation of the Anti-osteoporosis and Antioxidant Activities of Phenolic Compounds from Euphorbia maculata
【24h】

Evaluation of the Anti-osteoporosis and Antioxidant Activities of Phenolic Compounds from Euphorbia maculata

机译：大戟中酚类化合物的抗骨质疏松和抗氧化活性的评价

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Antioxidant and anti-osteoporosis activities of extracts and chemical constituents from the whole plant of Euphorbia maculata were investigated. The MeOH extract, as well as EtOAc and H2O fractions (10.0 mu g/mL), exhibited potent antioxidant activities. Their oxygen radical absorbance capacity and cupric ion reducing antioxidant capacity values were 27.07 +/- 0.31 to 28.47 +/- 0.36 and 43.86 +/- 0.26 to 46.67 +/- 0.34 fold higher than those of 1.0 mu M Trolox, respectively. The MeOH extract and EtOAc fraction (at 10.0 mu g/mL) also significantly suppressed excessive bone resorption by osteoclasts with tartrate-resistant acid phosphatase (TRAP) activity values of 154.90 +/- 4.25 and 163.95 +/- 9.77%, respectively. Bioassay guided isolation of the EtOAc and H2O fractions afforded 19 known compounds (1-19). Of these, compounds 18, and 13-15 showed good antioxidant activity based on peroxyl radical-scavenging and reducing capacity assays, whereas compounds 1, 4, 7, and 14 showed the most significant inhibitory effect with TRAP activity values ranging from 121.31 +/- 1.41 to 110.00 +/- 3.74% relative to the control
机译：研究了大戟整个植物的提取物和化学成分的抗氧化和抗骨质疏松活性。 MeOH萃取液以及EtOAc和H2O馏分（10.0μg / mL）表现出强大的抗氧化活性。它们的氧自由基吸收能力和还原铜离子的抗氧化剂能力值分别比1.0μM Trolox高27.07 +/- 0.31至28.47 +/- 0.36和43.86 +/- 0.26至46.67 +/- 0.34倍。 MeOH提取物和EtOAc馏分（10.0μg / mL）也显着抑制破骨细胞的过量骨吸收，抗酒石酸的酸性磷酸酶（TRAP）活性值分别为154.90 +/- 4.25和163.95 +/- 9.77％。生物测定法指导的EtOAc和H2O馏分分离得到19种已知化合物（1-19）。其中，化合物18和13-15基于过氧自由基清除和还原能力分析显示出良好的抗氧化活性，而化合物1、4、7和14显示出最显着的抑制作用，TRAP活性值为121.31 + /。 -相对对照为1.41至110.00 +/- 3.74％

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号