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首页> 外文期刊>Journal of the mechanical behavior of biomedical materials >Rheological, mucoadhesive and textural properties of thermoresponsive polymer blends for biomedical applications
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Rheological, mucoadhesive and textural properties of thermoresponsive polymer blends for biomedical applications

机译：用于生物医学应用的热敏性聚合物共混物的流变，粘膜粘附和质地特性

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The development of binary polymeric mixtures (polymer blends) containing bioadhesive and thermoresponsive polymers can provide new materials for biomedical applications, with higher contact, increased adhesion, prolonged residence time, protection, and in determined cases, secured absorption of an active agent from the site of application. Mixtures were prepared using a wide range of poloxamer 407 and Carbopol 971P (R) amounts. The rheological (flow and oscillatory), sol-gel transition temperature, mechanical (hardness, compressibility, adhesiveness, cohesiveness and elasticity), softness, and mucoadhesive properties of formulations were investigated. Moreover, the interaction between the different proportions of polymers was also analyzed. Continuous shear and oscillatory rheometry identified the plastic flow with various degrees of thixotropy, besides the viscoelastic behavior of formulations. The determination of gelation temperature displayed values ranged from 27.17 to 41.09 degrees C. It was also found that low carbomer concentrations were enough to provide positive interaction parameter. However, the highest values were obtained for the polymeric blends with higher concentration of poloxamer 407. The mucoadhesion and softness index were greater in preparations containing 20% (w/w) poloxamer 407. The rheological, mechanical and mucoadhesive properties of the polymeric blends can be manipulated by changing the concentrations of the polymers and they suggest the blends are worthy of biomedical applications. (C) 2015 Elsevier Ltd. All rights reserved.
机译：包含生物粘合剂和热敏性聚合物的二元聚合物混合物（聚合物共混物）的开发可以为生物医学应用提供新的材料，具有更高的接触性，增加的粘附性，延长的停留时间，保护作用，并在确定的情况下确保从现场吸收活性剂的应用程序。使用多种泊洛沙姆407和Carbopol 971P（R）量制备混合物。研究了制剂的流变（流动和振荡），溶胶-凝胶转变温度，机械（硬度，可压缩性，粘合性，内聚性和弹性），柔软性和粘膜粘附特性​​。此外，还分析了不同比例的聚合物之间的相互作用。连续剪切和振荡流变学确定了具有不同触变性程度的塑性流，除了配方的粘弹行为外。凝胶温度显示值的测定范围为27.17至41.09℃。还发现低卡波姆浓度足以提供正相互作用参数。但是，具有较高浓度泊洛沙姆407的聚合物共混物获得了最高值。在含有20％（w / w）泊洛沙姆407的制剂中，粘膜粘附性和柔软指数更高。聚合物共混物的流变，机械和粘膜粘附性能通过改变聚合物的浓度进行操作，他们认为这些混合物值得生物医学应用。 （C）2015 Elsevier Ltd.保留所有权利。

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